摘要
目的探析丙硫氧嘧啶联合普萘洛尔治疗妊娠期甲状腺功能亢进症(甲亢)患者的临床疗效。方法选取64例妊娠期甲亢患者为研究对象,将患者随机分为参照组和联合组,各32例。参照组给予丙硫氧嘧啶治疗,联合组在参照组基础上联合普萘洛尔治疗。对比两组甲状腺激素水平、妊娠结局、糖代谢指标水平及不良反应发生情况。结果联合组的游离三碘甲状腺原氨酸(FT_(3))、血清游离甲状腺素(FT_(4))水平均显著低于参照组,促甲状腺激素(TSH)水平高于参照组(P<0.05)。联合组妊娠结局优于参照组(P<0.05)。治疗后,两组空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)水平相比治疗前有明显降低,但联合组FPG、FINS、TC及TG水平比参照组更低(P<0.05)。联合组不良反应发生率3.13%相比参照组的18.75%更低(P<0.05)。结论妊娠期甲亢患者实施丙硫氧嘧啶联合普萘洛尔治疗,可有效改善患者甲状腺激素及糖代谢指标水平,改善妊娠结局,减少不良反应发生风险。
Objective To explore the clinical efficacy of propithiouracil combined with propranolol in the treatment of hyperthyroidism during pregnancy.Methods 64 cases of hyperthyroidism during pregnancy were selected as the study objects,and the patients were randomly divided into the reference group and the combination group,32 cases each.The reference group was treated with propylthiouracil and the combination group was treated with propranolol on the basis of the reference group.Thyroid hormone levels,pregnancy outcomes,glucose metabolism indexes and adverse reactions were compared between the two groups.Results The levels of free triodothyronine(FT_(3))and serum free thyroxine(FT_(4))in combination group were significantly lower than those in reference group,and the levels of thyroid stimulating hormone(TSH)were higher than those in reference group(P<0.05).The pregnancy outcome of the combined group was better than that of the reference group(P<0.05).After treatment,the levels of fasting blood glucose(FPG),fasting insulin(FINS),total cholesterol(TC)and triacylglycerol(TG)in the two groups were significantly decreased compared with before treatment,but the levels of FPG,FINS,TC and TG in the combined group were lower than those in the reference group(P<0.05).The incidence of adverse reactions(3.13%)in the combination group was lower than that in the reference group(18.75%)(P<0.05).Conclusion The combination of propylthiouracil and propranolol in hyperthyroidism during pregnancy can effectively improve the levels of thyroid hormone and glucose metabolism indexes,improve pregnancy outcomes,and reduce the risk of adverse reactions.
作者
刘卫
程海兵
曾雅娟
Liu Wei;Cheng Haibing;Zeng Yajuan(Department of Obstetrics and Gynecology,Hengli Hospital,Dongguan 523460,China)
出处
《实用妇科内分泌电子杂志》
2023年第6期70-72,共3页
Electronic Journal of Practical Gynecological Endocrinology
