摘要
一测多评法(QAMS法)是通过采用一种对照品同时测定多种成分含量的定性定量分析方法,具有高选择性、经济、准确等特点,目前在化学药物、中药及其制剂的含量测定中已得到推广应用。简述了QAMS法建立流程,综述了近年来QAMS法在化学药物定量分析、中药的化学药物成分、中药违法添加化学药物及药物杂质的定性定量分析中的研究进展,并对其应用前景进行了展望。
Quantitative analysis of multi-components with a single marker(QAMS)is a method for detecting multiple components by using an internal reference substance.Due to its advantage of selectivity,economy,and accuracy,QAMS has been widely used in the content determination of chemical drugs,traditional Chinese medicine and their preparations.This article summarizes the technical establishment process of QAMS method.The review also encompasses the research progress of QAMS method in the qualitative and quantitative analysis of chemical drugs,chemicals drugs in traditional Chinese medicine,chemical drug compositions illegally added in traditional Chinese medicines and drug impurities in recent years.Moreover,the prospects of its applications are also discussed.
作者
方宝霞
李湘
滚代芬
秦静雨
陈富超
FANG Baoxia;LI Xiang;GUN Daifen;QIN Jingyu;CHEN Fuchao(Department of Pharmacy,Sinopharm Dongfeng General Hospital,Hubei University of Medicine,Shiyan 442008,China;College of Pharmacy,Hubei University of Medicine,Shiyan 442000,China)
出处
《药物评价研究》
CAS
2023年第6期1382-1388,共7页
Drug Evaluation Research
基金
十堰市科学技术研究与开发计划项目(21Y75)。
关键词
一测多评法
相对校正因子
光谱相似度
相对容量因子
化学药物
中药
quantitative analysis of multi-components with single marker(QAMS)
relative correction factor
UV spectrum similarity
relative calibration factors
chemical drug
traditional Chinese medicine
