摘要
目的:基于国家专利数据库,分析动脉粥样硬化中药复方专利配伍规律,比较不同部位动脉粥样硬化用药规律的异同。方法:提取国家专利数据库建库至2022年8月31日治疗动脉粥样硬化的中药复方专利,运用中医传承计算平台(V3.0)软件中频次分析、关联规则分析和聚类分析等方法,探究动脉粥样硬化整体及不同部位的组方规律。结果:共纳入313首研究方剂,涉及脑动脉、冠状动脉、颈动脉、下肢动脉4种特定部位动脉粥样硬化。治疗动脉粥样硬化整体用药以性温、味甘、入肝经为主,常用补虚药、活血化瘀药,最常用对药为“丹参、黄芪”,最常用角药为“丹参、川芎、山楂”。但针对不同部位的用药存在一定程度差异,如脑动脉粥样硬化中川芎使用频次最高;冠状动脉粥样硬化中丹参使用频次较高;颈动脉粥样硬化苦味药占比最大,“葛根→丹参”关联度最强;下肢动脉粥样硬化以黄芪为核心用药,“鸡血藤→丹参”关联度最高。结论:动脉粥样硬化中药复方专利多以补气活血为基础,同时注重特殊部位动脉粥样硬化的辨病用药,把握关键治法,使药直达病所,为临床治疗和新药开发提供了参考。
Objective:Based on the national patent database,the medication regularities of traditional Chinese medicine compound patents for atherosclerosis were analyzed,and the similarities and differences of the medication rules of atherosclerosis at different parts were compared.Methods:The traditional Chinese medicine compound patents for atherosclerosis in the national patent database from the establishment to August 31,2022 were collected,and the frequency analysis,association rule analysis,and cluster analysis in the traditional Chinese medicine inheritance computing platform(V3.0) were performed to explore the medication regularities of atherosclerosis.Results:There were 313 traditional Chinese medicine compound patents included,involving four specific sites of atherosclerosis:cerebral artery,coronary artery,carotid artery,and lower limb artery.The medicine was mainly with the properties of warm,with the taste of sweet,and with the meridian of liver.The commonest pair and corner herb were "Salvia miltiorrhiza and Astragalus membranaceus" and "Salvia miltiorrhiza,Chuanxiong,and Crataegi Fructus".However,there were some degree of variation in medication use for different sites of atherosclerosis.For example,Chuanxiong were used more frequently in cerebral atherosclerosis.Salvia miltiorrhiza were used more frequently in coronary atherosclerosis.Carotid atherosclerosis was trented with bitter-taste Chinese herb,and the association between "Pueraria lobata→Salvia miltiorrhiza" was the strongest.Lower limb atherosclerosis had Astragalus as the core drug,and the association between "Spatholobi Caulis→Salvia miltiorrhiza" was the strongest.Conclusion:Most of traditional Chinese medicine compound patents for atherosclerosis are based on tonify qi and activate blood,its use are based on the identification of specific parts of atherosclerosis.This study provides a reference for clinical treatment and new drug development to a certain extent.
作者
彭煜暄
李洪峥
黄明艳
廖飞飞
杨文文
魏玥
路爱梅
龙霖梓
付长庚
PENG Yuxuan;LI Hongzheng;HUANG Mingyan;LIAO Feifei;YANG Wenwen;WEI Yue;LU Aimei;LONG Linzi;FU Changgeng(Graduate School of Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中西医结合心脑血管病杂志》
2023年第13期2340-2347,共8页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家中医心血管病临床医学研究中心专项科研基金课题(No.CMC2022010)。
关键词
动脉粥样硬化
专利中药复方
用药规律
数据挖掘
atherosclerosis
traditional Chinese medicine compound patents
medication regularities
data-mining approach
