摘要
目的:研究平冲降逆通络汤^(+)来曲唑用于子宫内膜异位症中的价值。方法:选择2021年8月-2022年5月江西中医药大学附属医院收治的子宫内膜异位症患者80例,通过简单随机分配法进行分组,每组40例。研究组予以平冲降逆通络汤^(+)来曲唑治疗,对照组予以来曲唑治疗。观察两组总有效率、黄体生成素(LH)、卵泡刺激素(FSH)、孕酮(P)、雌二醇(E2)、肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)、白介素-1β(IL-1β)、白介素-6(IL-6)、T淋巴细胞(CD4^(+)、CD3^(+)、CD8^(+)、CD4^(+)/CD8^(+))、卵巢体积、窦卵泡计数、中医症状积分。结果:研究组总有效率(92.50%)高于对照组(75.00%),差异有统计学意义(P<0.05)。用药前两组性激素水平比较,差异均无统计学意义(P>0.05);研究组用药后的LH、FSH、P、E2均较对照组低,差异均有统计学意义(P<0.05)。用药前两组炎症指标比较,差异均无统计学意义(P>0.05);研究组用药后的TNF-α、IL-8、IL-1β、IL-6均较对照组低,差异均有统计学意义(P<0.05)。用药前两组卵巢功能比较,差异均无统计学意义(P>0.05);研究组用药后的卵巢体积、窦卵泡计数均优于对照组,差异均有统计学意义(P<0.05)。用药前两组中医症状积分比较,差异均无统计学意义(P>0.05);研究组用药后的各项中医症状积分均较对照组低,差异均有统计学意义(P<0.05)。用药前两组免疫指标比较,差异均无统计学意义(P>0.05);研究组用药后的CD4^(+)、CD3^(+)、CD4^(+)/CD8^(+)均较对^(+)照组高,CD8低于对照组,差异均有统计学意义(P<0.05)。结论:平冲降逆通络汤^(+)来曲唑的治疗效果更为理想,可有效改善性激素及卵巢功能,减轻炎症反应,同时快速缓解相关症状,调节患者免疫功能。
Objective:To study the value of Pingchong Jiangni Tongluo Decoction^(+)Letrozol in the treatment of endometriosis.Method:A total of 80 patients with endometriosis admitted to the Affiliated Hospital of Jiangxi University Chinese Medicine from August 2021 to May 2022 were selected and divided into groups by simple random distribution method,with 40 cases in each group.The study group was treated with Pingchong Jiangni Tongluo Decoction^(+)Letrozol,and the control group was treated with Letrozol.The total effective rate,luteinizing hormone(LH),follicle stimulating hormone(FSH),progesterone(P),estradiol(E2),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),interleukin-1β(IL-1β),interleukin-6(IL-6),T lymphocyte(CD4^(+),CD3^(+),CD8^(+),CD4^(+)/CD8^(+)),ovarian volume,antral follicle count,TCM symptoms scores in the two groups were observed.Result:The total effective rate of the study group(92.50%)was higher than that of the control group(75.00%),the difference was statistically significant(P<0.05).There were no significant differences in gonadal hormone levels between the two groups before treatment(P>0.05);LH,FSH,P and E2 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in inflammatory indexes between the two groups before treatment(P>0.05);the levels of TNF-α,IL-8,IL-1βand IL-6 in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in ovarian function between the two groups before treatment(P>0.05);the ovarian volume and the antral follicle count in the study group were better than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in TCM symptoms scores between the two groups before treatment(P>0.05);the scores of TCM symptoms in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).There were no significant differences in immune indexes between the two groups before treatment(P>0.05);CD4^(+),CD3^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group,CD8^(+)was lower than that of control group,the differences were statistically significant(P<0.05).Conclusion:The therapeutic effect of Pingchong Jiangni Tongluo Decoction^(+)Letrozol is more ideal,which can effectively improve gonadal hormone and ovarian function,reduce inflammatory reaction,and at the same time quickly relieve related symptoms and regulate patients'immune function.
作者
刘玉玲
方家
陈姣洁
梁瑞宁
袁紫文
李佳雪
LIU Yuling;FANG Jia;CHEN Jiaojie;LIANG Ruining;YUAN Ziwen;LI Jiaxue(The Affiliated Hospital of Jiangxi University Chinese Medicine,Nanchang 330006,China)
出处
《中国医学创新》
CAS
2023年第17期63-67,共5页
Medical Innovation of China
基金
2022年度江西省卫生健康委科技计划项目(202310689)。
关键词
子宫内膜异位症
平冲降逆通络汤
来曲唑
卵巢功能
性激素
Endometriosis
Pingchong
Jiangni
Tongluo
Decoction
Letrozol Ovarian function
Gonadal hormone
