摘要
B细胞的体液免疫应答是机体特异性免疫保护的关键,免疫衰老将重塑其生成和功能。B细胞免疫功能下降是免疫衰老的重要因素之一。B细胞分泌抗体介导的体液免疫功能受损,导致老年个体对疫苗的应答下降、更易感染且趋于严重化、肿瘤和代谢性疾病等发病率增加。激活诱导的胞苷脱氨酶(AID)是触发免疫球蛋白类别转换重组(CSR)和体细胞高频突变(SHM)的酶,在免疫衰老过程中减少,被认为是衰老的小鼠和人类B细胞功能下降的生物标志物。明确B细胞免疫衰老的固有缺陷以及衰老过程中AID的调控机制,可为老年人对疾病的易感、预防及治疗提供新的研究思路。
The humoral immune response of B cells is the key to the protection of specific immunity,and immune aging reshapes its production and function.The decreased B cell immune function is an indicator of immune senescence.The impaired humoral immune function mediated by antibody secreted by B cells leads to a decline in the response of elderly individuals to the vaccine.These people are therefore more susceptible to infection and deterioration,and have a higher incidence of tumors and metabolic diseases.Activation⁃induced cytidine deaminase(AID)is an enzyme that triggers immunoglobulin class conversion recombination(CSR)and somatic high frequency mutation(SHM).It decreases during immune senescence and is considered to be a biomarker of decreased B cell function in aging mice and humans.Understanding the inherent defects of B⁃cell immune senescence and the regulation mechanism of AID in the aging process can provide new research ideas for the susceptibility,prevention and treatment of diseases in the elderly.
作者
肖佳萍
李俊
姚新生
XIAO Jiaping;LI Jun;YAO Xinsheng(Department of Immunology,Zunyi Medical University,Zunyi 563000,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2023年第5期474-478,共5页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81860300)
贵州省百层次人才基金[(2018)5637]。
关键词
免疫衰老
B淋巴细胞
体液免疫
激活诱导型胞苷脱氨酶
疫苗
综述
immunosenescence
B lymphocyte
humoral immunity
activation⁃induced cytidine deaminase(AID)
vaccination
review
