摘要
目的:对2015—2020年广西卡介苗疑似预防接种异常反应(AEFI)监测数据进行分析,描述广西卡介苗AEFI发生率空间分布趋势,查找对卡介苗AEFI发生率的影响因素,从而减少卡介苗接种异常反应的发生。方法:通过开展问卷调查111个县区免疫规划经费人员投入情况和业务工作情况,使用空间自相关分析、地理加权回归分析等方法从数理和空间上进行卡介苗AEFI发生率影响因素分析。结果:2015—2020年广西卡介苗AEFI发生率20.31/10万,免疫规划工作经费是否达到人均1元、是否配备自动温度监控设备及接种事故发生率是卡介苗AEFI发生率的影响因素(P<0.05)。卡介苗AEFI发生率具有空间自相关性,Moran’s I指数=0.173,Z=2.677,P=0.007;卡介苗AEFI发生率高—高聚集区的桂北部主要受预防接种人员数量、接种事故发生率、温度监测设备的配备、上卡率的影响;桂东部主要受接种事故发生率、免疫规划人员数量影响;桂西北部主要受经费投入、预防接种人员数量和上卡率的影响。结论:广西卡介苗AEFI发生率具有空间自相关性,不同区域各因素的影响程度不同,各地可通过制定适宜的政策措施,降低接种差错和卡介苗AEFI发生率。
Objective:To analyze the monitoring data of Adverse Events Following Immunization(AEFI)of BCG vaccination in Guangxi from 2015 to 2020,to describe the spatial distribution trend of the AEFI incidence of BCG vaccination in Guangxi,and to find the influencing factors on the incidence of BCG vaccination,so as to reduce the occurrence of adverse reaction to BCG vaccination.Methods:Through questionnaire surveys,personnel investment and business work of immunization programs in 111 counties and districts,spatial autocorrelation analysis and geographically weighted regression analysis were used to analyze the influencing factors of the AEFI incidence of BCG accination from mathematics and space.Results:From 2015 to 2020,the AEFI incidence of BCG vaccination in Guangxi was 20.31/100,000.Whether the immunization program expenditure reached 1 yuan per capita,whether it was equipped with automatic temperature monitoring equipment and the incidence of vaccination accidents were the influencing factors of the AEFI incidence of BCG vaccination(P<0.05).The AEFI incidence of BCG vaccination was spatially autocorrelated,with Moran's I index=0.173,Z=2.677 and P=0.007.In the northern Guangxi of the high-high aggregation area with AEFI incidence of BCG vaccine,the main factors influencing it were the number of vaccination personnel,the incidence of vaccination accidents,the allocation of temperature monitoring equipment and the rate of registration.In eastern Guangxi,the main factors influencing it were the incidence of vaccination accidents and the number of immunization program personnel.In northwest Guangxi,the main factors influencing it were funding,the number of vaccination personnel and the rate of registration.Conclusion:The AEFI incidence of BCG vaccination in Guangxi is spatially autocorrelated,and the degree of influence of each factor varies in different regions.Therefore,each region can reduce vaccination errors and the AEFI incidence of BCG vaccination by formulating appropriate policy measures.
作者
黄影
邓秋云
韦佳楠
杜进发
唐咸艳
蒋俊俊
Huang Ying;Deng Qiuyun;Wei Jianan;Du Jinfa;Tang Xianyan;Jiang Junjun(Guangxi Medical University,Nanning 530021,China;Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2023年第5期884-890,共7页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.81960615)
广西壮族自治区卫健委自筹课题资助项目(No.Z20180989)。
关键词
卡介苗
预防接种异常反应
影响因素
空间特征
BCG
Adverse Events Following Immunization
influencing factors
spatial characteristics
