摘要
目的探讨耳后注射甲泼尼龙琥珀酸钠联合复方甘草酸苷对突发性耳聋患者的疗效。方法选取2019年5月至2022年12月收治的突发性耳聋患者116例,采用随机信封法平均分为对照组和治疗组各58例,对照组采用耳后注射甲泼尼龙琥珀酸钠,治疗组在对照组基础上增加复方甘草酸苷,均治疗2周。比较两组疗效、血液流变学指标变化以及炎症因子水平等。结果治疗2周后,治疗组患者治疗有效率(94.83%)明显高于对照组(79.31%),纯音听阈值低于对照组(P<0.05);两组血液流变学指标(血浆黏度、血小板聚集率、血细胞比容)水平以及炎症因子(白介素-6、肿瘤坏死因子、C反应蛋白)水平均下降,且治疗组低于对照组(P<0.05)。两组患者均无明显不良反应。结论耳后注射甲泼尼龙琥珀酸钠联合复方甘草酸苷的治疗方案可显著改善突聋患者的血液流变学,减轻炎症因子表达,疗效显著且安全性良好。
Objective To investigate the curative effect of retroauricular injectionof methylprednisolone sodium succinate combined with compound glycyrrhizin in the treatment of sudden deafness.Methods A total of 116 patients with sudden deafness from May 2019 to December 2022 were selected.The patients were randomly divided into a control group and a treatment group by using a random envelope method,58 in each group.The control group was treated with retroauricular injection of methylprednisolone sodium succinate.The treatment group was supplemented with compound glycyrrhizin.The curative effect,changes in hemorheological chemical indicators and levels of inflammatory factors were compared between the two groups.Results After 2 weeks of treatment,the effective rate of the treatment group was 9483%,that was significantly higher than 793%of the control group,and the pure tone hearing threshold value of the treatment group was lower than that of the control group(P<0.05).The levels of hemorheological indicators such as plasma viscosity,platelet aggregation rate and hematocrit and the levels of inflammatory factors such as interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)were decreased in both groups,and the levels of the above indicators in the treatment group were lower than those in the control group(P<0.05).There were no obvious adverse reactions in the two groups.Conclusions The treatment of methylprednisolone sodium succinate combined with compound glycyrrhizin can significantly improve the hemorheology of patients with sudden deafness and reduce the level of inflammatory factors.The curative effect is significant and its safety is good.
作者
王潇
李盈
阳志慧
晋舒
WANG Xiao;LI Ying;YANG Zhi-hui;JIN Shu(Department of Otolaryngology,Head and Neck Surgery,Ziyang Hospital,West China Hospital of Sichuan University,Ziyang First People′s Hospital,Ziyang 641300,China)
出处
《实用医院临床杂志》
2023年第4期126-129,共4页
Practical Journal of Clinical Medicine
基金
成都市卫生健康委员会科研课题(编号:2020142)。
关键词
突发性耳聋
甲泼尼龙琥珀酸钠
复方甘草酸苷
血液流变学
炎症因子
Sudden deafness
Injection of methylprednisolone sodium succinate
Compound glycyrrhizin
Hemorheology
In-flammatory factors
