摘要
目的探讨Life′s Simple 7(LS7)干预减轻Her⁃2阳性乳腺癌患者根治术后化疗相关心血管系统损害的作用。方法将120例Her⁃2阳性并接受标准化乳腺癌化疗的患者随机等量分为对照组及LS7组,对照组为标准化疗方案,LS7组为对照组基础上给予LS7干预12个月,后续通过比较两组治疗前后心血管系统损伤程度、焦虑、抑郁及生活质量等指标评价其对心血管系统损害的改善作用。结果相较于对照组,LS7组LS7总评分及7项心血管健康指标均优于对照组(P<0.05),LS7组LVEF较高(P<0.05)、NT⁃proBNP较低(P<0.05),焦虑和抑郁评分较低(P<0.05)、生活质量评分较高(P<0.05)。结论LS7干预可显著减轻Her⁃2阳性乳腺癌化疗相关心血管系统损害并改善乳腺癌患者的心理状况和生活质量,值得在临床推广。
Objective To investigate the effect of Life′s Simple 7(LS7)intervention on chemotherapy⁃related cardiovascular system damage in HER2 positive patients with breast cancer after radical surgery.Methods A total of 120 HER2 positive patients who received standardized chemotherapy for breast cancer were randomly divided into control group and LS7 group.The control group was addressed with standard chemotherapy scheme,and LS7 group was treated with LS7 intervention for 12 months on the basis of the control group.The improvement effect of cardiovascular system damage in the two groups was evaluated by comparing the degree of cardiovascular system damage,anxiety,depression,and quality of life before and after treatment.Results Compared with the control group,the LS7 group had better overall LS7 score and 7 cardiovascular health indicators(P<0.05).The LS7 group had higher LVEF(P<0.05),lower NT⁃proBNP(P<0.05),lower anxiety and depression score(P<0.05),and higher quality of life score(P<0.05).Conclusion LS7 intervention can significantly reduce chemotherapy⁃related cardiovascular system damage in HER2 positive breast cancer patients and improve the mental health and quality of life of breast cancer patients,which is worthy of clinical promotion.
作者
吴军
崔伟燕
李平
张青凤
欧月珍
WU Jun;CUI Weiyan;LI Ping;ZHANG Qingfeng;OU Yuezhen(Department of Oncology I,Guangdong Second Provincial General Hospital,Guangzhou 510317,China)
出处
《实用医学杂志》
CAS
北大核心
2023年第13期1647-1651,1656,共6页
The Journal of Practical Medicine
基金
广东省医学科学技术研究项目(编号:B2020134)。
