摘要
大环内酯类抗生素是治疗儿童肺炎支原体(MP)感染的一线药物,但随着此类药物在临床中的广泛使用,对大环内酯类抗生素耐药的MP菌株检出率迅速增高。耐药机制相关研究中,对药物作用靶点的研究最多见,其中23S rRNA基因突变相关研究尤为广泛和深入。耐药性会影响药物治疗效果,探讨菌株对药物的耐药机制并合理调整药物治疗方案,可获得更好的治疗效果,现将大环内酯类抗生素的作用机制和MP对大环内酯类抗生素的耐药机制综述如下。
Macrolide antibiotics are the first-line drugs for the treatment of Mycoplasma pneumoniae(MP)infections in children,but with the increased use of macrolides,the detection rate of resistant strains of MP to macrolides has increased rapidly.Among the studies related to the mechanisms of drug resistance,the study of drug targets has been the most extensive and intensive,with mutations in the 23S rRNA gene being studied most extensively.The emergence of drug resistance affects the therapeutic efficacy of drugs,and the mechanisms of drug resistance need to be explored to adjust the choice of therapeutic agents in order to achieve higher therapeutic efficacy.This paper reviewed the mechanisms of action of macrolides and the mechanisms of resistance to macrolides by MP.
作者
汪慧华
邹映雪
WANG Huihua;ZOU Yingxue(Postgraduate College of Tianjin Medical University,Tianjin,300350;Respiratory Department,Tianjin Children′s Hospital,Tianjin,300350)
出处
《实用临床医药杂志》
2023年第12期136-140,148,共6页
Journal of Clinical Medicine in Practice
基金
天津市卫健委重点学科专项课题(TJWJ2022XK038)
天津市医学重点学科(专科)建设项目资助(TJYXZDXK-040A)。
关键词
肺炎支原体
大环内酯类抗生素
耐药机制
儿童
基因突变
Mycoplasma pneumoniae
macrolide antibiotics
drug resistance mechanisms
children
gene mutations
