摘要
目的探究左乙拉西坦联合奥卡西平治疗癫痫患儿的效果。方法选取2020年8月至2022年7月中山市博爱医院儿科收治92例癫痫患儿作为研究对象,按随机数字表法分为对照组(46例)与研究组(46例),比较两组脑电图治疗效果、免疫功能[免疫球蛋白(Ig):IgA、IgM、IgG、T淋巴细胞亚群:CD3^(+)、CD4^(+)]、认知功能[总智商(FIQ)、操作智商(PIQ)、计算语言智商(VIQ)]和不良反应。结果研究组治疗后脑电图治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组IgA、IgM、IgG、CD3^(+)、CD4^(+)水平比较,差异无统计学意义(P>0.05);治疗后,两组IgA、IgM、IgG水平低于治疗前,CD3^(+)、CD4^(+)水平高于本组治疗前,且研究组IgA、IgM、IgG水平低于对照组,CD3^(+)、CD4^(+)水平高于对照组,差异有统计学意义(P<0.05)。治疗前,两组FIQ、PIQ、VIQ分数比较,差异无统计学意义(P>0.05);治疗后,两组FIQ、PIQ、VIQ分数高于本组治疗前,且研究组FIQ、PIQ、VIQ分数高于对照组,差异有统计学意义(P<0.05);治疗后两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论左乙拉西坦联合奥卡西平能有效改善癫痫患儿的脑电图痫样放电,利于调节患儿免疫功能,减少对患儿认知功能的损伤,安全可靠。
Objective To explore the effect of Levetiracetam combined with Oxcarbazepine in the treatment of children with epilepsy.Methods From August 2020 to July 2022,92 children with epilepsy admitted to the Department of Pediatrics of Boai Hospital Of Zhongshan were selected as the study subjects.They were divided into the control group(46 cases)and the study group(46 cases)according to random number table method.The therapeutic effect of EEG and immune function(immunoglobulin[Ig]:IgA,IgM,IgG,T lymphocyte subgroup:CD3^(+),CD4^(+))cognitive function(full intelligence quotient[FIQ],performance intelligence quotient[PIQ],verpal intelligence quotient[VIQ]),and adverse reactions of the two groups were compared.Results The total effective rate of EEG treatment in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in the levels of IgA,IgM,IgG,CD3^(+)and CD4^(+)between the two groups(P>0.05).After treatment,the levels of IgA,IgM and IgG in the two groups were lower than those before treatment,and the levels of CD3^(+)and CD4^(+)were higher than those before treatment,the levels of IgA,IgM and IgG in the study group were lower than those in the control group,and the levels of CD3^(+)and CD4^(+)were higher than those in the control group,with statistically significant differences(P<0.05).Before treatment,the scores of total intelligence quotient(FIQ),operational intelligence quotient(PIQ),computational language intelligence quotient(VIQ)in the two groups were not significantly different(P>0.05).After treatment,the scores of FIQ,PIQ and VIQ in the two groups were higher than those before treatment,and the scores of FIQ,PIQ and VIQ in the study group were higher than those in the control group,with statistically significant differences(P<0.05).After treatment,there was no statistically significant difference in total incidence of adverse reactions between the two groups(P>0.05).Conclusion Levetiracetam combined with Oxcarbazepine can effectively improve the epileptiform discharge of electroencephalogram in children with epilepsy,help regulate the immune function of children,reduce the damage to cognitive function of children,and is safe and reliable.
作者
刘楠
谢惠源
李尖
朱建萍
LIU Nan;XIE Huiyuan;LI Jian;ZHU Jianping(Department of Pediatrics,Boai Hospital Of Zhongshan,Guangdong Province,Zhongshan 528400,China)
出处
《中国当代医药》
CAS
2023年第21期80-83,共4页
China Modern Medicine
关键词
儿童癫痫
左乙拉西坦
奥卡西平
免疫功能
认知功能
Epilepsy in children
Levetiracetam
Oxcarbazepine
Immunity
Cognitive function
