摘要
目的 探究慢性阻塞性肺疾病急性加重期患者肺功能指标与炎症指标的相关性。方法 选取2022年3月至8月江苏省如皋市人民医院呼吸内科接诊的68例慢性阻塞性肺疾病患者,根据疾病状态分为稳定期组(31例)和急性加重期组(37例)。比较两组血清白细胞介素-33(IL-33)、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、红细胞分布宽度(RDW)、用力肺活量(FVC)、呼气流量峰值(PEF)、第1秒用力呼气容积/用力肺活量(FEV1/FVC),分析急性加重期患者肺功能指标与炎症指标及外周血指标的相关性。结果 急性加重期组FVC、PEF、FEV1/FVC低于稳定期组,IL-33、CRP、TNF-α、NLR、PLR、RDW高于稳定期组(P<0.05)。急性加重期患者FVC与IL-33、CRP、PLR呈负相关;PEF与IL-33、TNF-α、NLR、PLR呈负相关;FEV1/FVC与IL-33、TNF-α、NLR、RDW呈负相关(r<0,P<0.05)。结论 CRP、NLR、PLR、RDW等因子与慢性阻塞性肺疾病患者肺功能指标具有相关性,可用于辅助评估慢性阻塞性肺疾病患者的病情变化。
Objective To explore the correlation between pulmonary function indicators and inflammatory indicators in patients with chronic obstructive pulmonary disease.Methods From March to August 2022,68 patients with chronic obstructive pulmonary disease admitted to the Department of Respiratory Medicine,Rugao People’s Hospital,Jiangsu Province were selected.They were divided into stable group(31 cases)and acute exacerbation group(37 cases)according to the disease status.Serum interleukin-33(IL-33),C-reactive protein(CRP),tumor necrosis factor(TNF-α),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),red blood cell distribution width(RDW),forced vital capacity(FVC),peak expiratory flow(PEF),forced expiratory volume in one second/forced vital capacity(FEV1/FVC)between two groups were compared;the correlation of lung function indicators and inflammatory factors indicators were analyzed.Results FVC,PEF,and FEV1/FVC in acute exacerbation group were lower than those in stable group,IL-33,CRP,TNF-α,NLR,PLR,and RDW were higher than those in stable group(P<0.05).In acute exacerbation patients,FVC was negatively correlated with IL-33,CRP,and PLR;PEF was negatively correlated with IL-33 and TNF-α,NLR,and PLR;FEV1/FVC was negatively correlated with IL-33 and TNF-α,NLR,and RDW(r<0,P<0.05).Conclusion Factors such as CRP,NLR,PLR,and RDW are correlated with pulmonary function indicators of patients with chronic obstructive pulmonary disease,which can be used to assist in assessing the disease changes in patients with chronic obstructive pulmonary disease.
作者
曹海燕
陈龙
储祥健
CAO Haiyan;CHEN Long;CHU Xiangjian(Department of Respiratory and Critical Care,Rugao People’s Hospital,Jiangsu Province,Rugao226500,China;Department of Respiratory Medicine,Rugao People’s Hospital,Jiangsu Province,Rugao226500,China;Department of Radiotherapy,Rugao People’s Hospital,Jiangsu Province,Rugao226500,China)
出处
《中国医药导报》
CAS
2023年第20期138-141,共4页
China Medical Herald
基金
江苏省卫生健康委员会科研项目(ZDB2020012)。
关键词
慢性阻塞性肺疾病
炎症指标
肺功能指标
相关性
Chronic obstructive pulmonary disease
Inflammatory indicators
Pulmonary function indicators
Correlation
