摘要
目的:基于数据挖掘技术总结儿童慢性咳嗽的中医证候分布特点及中药遣方用药规律。方法:检索中国知网、万方、维普、中国生物医学文献数据库中2006—2022年收录的中医药治疗儿童慢性咳嗽的临床观察或临床随机对照研究文献,运用SPSS26.0对纳入文献的中医证型、证素、中药进行频数统计和药物聚类分析,R4.2.1 apriori函数进行关联规则可视化分析,通过Cytoscape 3.9.1构建中药核心复杂网络。结果:共纳入文献122篇,涉及患者6328例,涵盖中医证型45种,出现频次前4位的证型依次为肺脾气虚、痰湿犯肺、痰热壅肺、风热犯肺。共提取出14个病性证素和5个病位证素,其中病性证素频次前6位依次为痰、热、外风、气虚、湿、阴虚,病位证素频次前2位为肺、脾。共使用处方150首,涉及药物163味,使用频次较高的前6味药物依次为甘草、苦杏仁、法半夏、茯苓、陈皮、桔梗。常用对药有茯苓-陈皮、陈皮-法半夏等,药组有法半夏-甘草-陈皮、茯苓-甘草-陈皮等。聚类分析结果显示,32味高频中药可聚为9类。结论:儿童慢性咳嗽应分清虚实表里,病位主要在肺、脾,虚性证素常见气虚、阴虚,实性证素主要为痰、热、湿,治疗以健脾益肺、祛风清热、化痰止咳为基本大法,随症加减。
Objective:To summarize the distribution characteristics of traditional Chinese medicine(TCM)syndromes of chronic cough in children and the rules of prescription of Chinese medicine based on data mining technology.Methods:To search the clinical observation or clinical randomized controlled study of TCM in treating chronic cough in children included in CNKI,Wanfang,VIP,and the Chinese Biomedical Literature Database from 2006 to 2022,SPSS26.0 was used to carry out frequency statistics and drug cluster analysis on the syndrome types,syndrome elements,and Chinese medicine included in the literature,and R4.2.1 apriori function was used to carry out visual analysis of association rules.The core complex network of Chinese medicine was established Cytoscape 3.9.1.Results:A total of 122 articles were included,involving 6328 patients,covering 45 types of TCM syndromes.The first four types of syndromes with frequency were lung and spleen qi deficiency,phlegm-damp invading the lung,phlegmheat blocking the lung,and wind-heat invading the lung.A total of 14 disease-related syndrome elements and 5 disease-position syndrome elements were extracted,of which the first six were phlegm,heat,external wind,qi deficiency,dampness and yin deficiency,and the first two types of disease location syndrome elements were lung and spleen.A total of 150 prescriptions were used,involving 163 drugs.The first six drugs with higher frequency of use were Glycyrrhizae Radix et Rhizoma,Armeniacae Semen Amarum,Pinelliae Rhizoma Praeparatum,Poria,Citri Reticulatae Pericarpium and Platycodonis Radix.Commonly used drug pairs include Poria-Citri Reticulatae Pericarpium,Citri Reticulatae Pericarpium-Pinelliae Rhizoma Praeparatum,etc.The drug groups include Pinelliae Rhizoma Praeparatum-Glycyrrhizae Radix et Rhizome-Citri Reticulatae Pericarpium,Poria-Glycyrrhizae Radix et Rhizome-Citri Reticulatae Pericarpium,etc.The results of cluster analysis showed that 32 high-frequency Chinese medicines could be grouped into 9 categories.Conclusion:Children's chronic cough should be divided into deficiency and excess,and the disease location is mainly in the lung and spleen.Deficiency syndrome elements are often qi deficiency and yin deficiency,while excess syndrome elements are mainly phlegm,heat and dampness.The basic treatment is to strengthen the spleen and benefit the lung,expel wind and clear heat,and dissipate phlegm and stop cough,and make modification according to symptoms.
作者
葛国岚
韩雪
潘丹萍
GE Guolan;HAN Xue;PAN Danping
出处
《新中医》
CAS
2023年第11期22-28,共7页
New Chinese Medicine
基金
国家中医药管理局第六批全国老中医药专家学术经验继承项目(国中医药人教发[2017]29号)
河南省中医药科学研究专项课题(2023ZY2168)。
关键词
儿童慢性咳嗽
中医证候
证素
用药规律
Chronic cough in children
Traditional Chinese medicine syndrome
Syndrome elements
Medication rule
