摘要
目的 基于Th1/Th2免疫失衡与Wnt/β-连环蛋白(Wnt/β-catenin)信号通路探讨清温解毒方联合甲基泼尼松龙治疗系统性红斑狼疮(SLE)的效果。方法 选取2019年2月—2022年2月收治的SLE 120例,根据治疗方法不同分为联合组和常规组2组各60例。联合组给予清温解毒方联合甲基泼尼松龙治疗,常规组给予甲基泼尼松龙治疗。比较2组治疗前和治疗3个月后血清Th1/Th2细胞因子、外周血单个核细胞中Wnt/β-catenin信号通路因子mRNA相对表达量、SLE疾病活动度(SLEDAI)评分、中医证候积分,以及治疗3个月后临床效果和治疗期间不良反应。结果 治疗3个月后,血清干扰素-γ(IFN-γ)、白细胞介素-12(IL-12)、IFN-γ/白细胞介素-4(IL-4)、IL-12/白细胞介素-10(IL-10)2组均高于治疗前,且联合组高于常规组;血清IL-4、IL-10,外周血单个核细胞中Wnt3a、β-catenin mRNA相对表达量和SLEDAI评分、中医证候积分2组均低于治疗前,且联合组低于常规组(P<0.05)。治疗3个月后,联合组总有效率高于常规组(P<0.05)。治疗期间,2组不良反应总发生率比较差异无统计学意义(P>0.05)。结论 清温解毒方联合甲基泼尼松龙治疗SLE患者能通过纠正Th1/Th2免疫失衡、调节Wnt/β-catenin信号通路加快临床症状消退,提高治疗效果,且安全性良好。
Objective To investigate the effect of Qingwen Jiedu recipe combined with Methylprednisolone on systemic lupus erythematosus(SLE)based on the immune imbalance of Th1/Th2 and Wnt/β-catenin pathway.Methods A total of 120 cases of SLE admitted from February 2019 to February 2022 were selected and divided into two groups according to different treatment methods:combination group and conventional group,with 60 cases in each group.The combination group was given Qingwen Jiedu recipe combined with Methylprednisolone treatment,and the conventional group was given Methylprednisolone treatment.Serum Th1/Th2 cytokines,relative mRNA expression levels of Wnt/β-catenin signaling pathway factors in peripheral blood mononuclear cells,SLE disease activity score(SLEDAI),TCM syndrome score before and at 3 months after treatment,clinical effect at 3 months after treatment and adverse reactions during treatment were compared between the two groups.Results At 3 months after treatment,serum interferon-γ(IFN-γ),interleukin-12(IL-12),IFN-γ/interleukin-4(IL-4),and IL-12/interleukin-10(IL-10)in both groups were higher than those before treatment,and higher in the combination group than in the conventional group.Serum IL-4 and IL-10,the relative expression levels of Wnt3a andβ-catenin mRNA,SLEDAI score and TCM syndrome score in peripheral blood mononuclear cells in the two groups were lower than those before treatment,and lower in the combination group than in the conventional group(P<0.05).At 3 months after treatment,the total effective rate of combination group was higher than that of conventional group(P<0.05).During treatment,there was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Qingwen Jiedu recipe combined with Methylprednisone in the treatment of SLE patients can accelerate the resolution of clinical symptoms by correcting Th1/Th2 immune imbalance,regulating Wnt/β-catenin signaling pathway,and improve the therapeutic effect,with good safety.
作者
王会娜
景伟芳
WANG Huina;JING Weifang(Department of Dermatology,the Fourth People's Hospital of Langfang,Langfang 065700,China;Department of Dermatology,Hebei Petro China Central Hospital,Langfang,Hebei 065000,China)
出处
《临床误诊误治》
CAS
2023年第6期133-137,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省卫生健康委员会科研基金项目(20191350)
廊坊市科技计划项目(2019013154)。
