摘要
目的:探讨阿替普酶静脉溶栓联合丁苯酞治疗对急性重症脑梗死患者神经功能和凝血功能的影响。方法:选取2022年2—12月新沂市人民医院收治的重症脑梗死患者65例为研究对象,随机分成常规组33例和研究组32例。常规组患者给予阿替普酶治疗,研究组患者在对照组基础上应用丁苯酞软胶囊治疗。比较两组治疗效果、神经功能恢复情况,进行凝血功能分析。结果:研究组患者治疗总有效率高于常规组,差异有统计学意义(P=0.014);治疗后,研究组患者神经功能缺损评分量表评分低于常规组,差异有统计学意义(P<0.001);治疗后,研究组患者血清凝血酶原时间、活化部分凝血活酶时间、凝血酶时间高于常规组,纤维蛋白原、平均通过时间低于常规组,差异有统计学意义(P<0.05)。结论:阿替普酶静脉溶栓联合丁苯酞治疗重症脑梗死患者的效果显著,能够有效改善患者神经功能和凝血功能,且不会增加不良反应,值得推广。
Objective:To investigate the effect of alteplase intravenous thrombolysis combined with butylphthalide on neurological function and coagulation function in patients with acute severe cerebral infarction.Methods:Sixty-five patients with severe cerebral infarction admitted to Xinyi People's Hospital from February to December 2022 were selected as the research objects.They were randomly divided into a routine group of thirty-three cases and a research group of thirty-two cases.Patients in routine group were treated with alteplase,and patients in study group were treated with butylphthalide soft capsules on the basis of control group.The treatment effect,nerve function recovery and blood coagulation function analysis were compared between the two groups.Results:The total effective rate of treatment in the research group was higher than that in the conventional group,and the difference was statistically significant(P=0.014).After treatment,the scores of the neurological deficit rating scale in the study group were lower than those in the routine group,and the difference was statistically significant(P<0.001).After treatment,the serum prothrombin time,activated partial thromboplastin time,and thrombin time in the study group were higher than those in the routine group,and the fibrinogen and average transit time were lower than those in the routine group,and the difference was statistically significant(P<0.05).Conclusion:Intravenous thrombolysis with alteplase combined with butylphthalide has a significant effect in the treatment of patients with severe cerebral infarction,can effectively improve the neurological function and blood coagulation function of patients,and will not increase adverse reactions,so it is worth popularizing.
作者
赵倩
Zhao Qian(Department of Neurology,Xinyi People's Hospital,Xinyi 221400,Jiangsu Province,China)
出处
《中外医药研究》
2023年第6期12-14,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
重症脑梗死
阿替普酶
丁苯酞
神经功能
凝血功能
Severe cerebral infarction
Alteplase
Butylphthalide
Neurological function
Coagulation function
