摘要
目的探讨自拟中药方剂联合远红外线治疗仪治疗小儿药物渗出或外渗的临床疗效及对患者血清超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)水平的影响。方法选取2020年1月—2022年6月石家庄市妇幼保健院儿科、中医儿科收治的输液时出现局部药物渗出或外渗的126例患儿作为研究对象,采取随机数字表法分为对照组和观察组,每组各63例。对照组患儿采取50%硫酸镁湿敷联合远红外线治疗仪治疗;观察组患儿采取自拟中药方剂外敷联合远红外线治疗仪治疗。观察治疗效果,对比2组视觉模拟评分(visual analogue scale,VAS)、皮肤症状恢复时间、SOD和GSH-Px水平。结果观察组治疗显效36例、有效27例、无效0例,对照组分别为22例、28例、13例,观察组治疗效果优于对照组(Z=-3.325,P=0.001)。观察组治疗24 h后VSA评分低于对照组(P<0.05)。观察组疼痛、炎症、红肿消退时间均短于对照组(均P<0.05)。观察组治疗24 h后SOD和GSH-Px水平均高于对照组(均P<0.05)。结论自拟中药方剂联合远红外线治疗仪治疗小儿药物渗出或外渗有良好的效果,其作用机制可能与其改善患儿血清SOD、GSH-Px有关。
Objective To explore the clinical efficacy of self-made traditional Chinese medicine prescription combined with far infrared therapeutic instrument in the treatment of drug exudation in children and its impact on the levels of serum superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)in patients.Methods A total of 126 children with local drug exudation or extravasation during infusion in the Pediatric and Traditional Chinese Medicine Pediatric Departments of Shijiazhuang Maternal and Child Health Hospital from January 2020 to June 2022 were selected as study subjects,and randomly divided into a control group and an observation group using a random number table method,with 63 patients in each group.The control group was treated with 50%magnesium sulfate wet compress combined with far infrared therapeutic instrument.The children in the observation group were treated with self-made traditional Chinese medicine prescription combined with combined with far infrared therapeutic instrument.The treatment effect was observed and the visual analog scale(VAS)score,skin symptom recovery time,SOD and GSH-Px levels between the two groups were compared.Results The observation group had 36 cases of significant effect,27 cases of effective treatment,and 0 cases of ineffective treatment,while the control group had 22 cases,28 cases and 13 cases,respectively.The treatment effect in the observation group was better than that in the control group(Z=-3.325,P=0.001).After 24 hours of treatment,the VSA score in the observation group were lower than those in the control group(P<0.05).The regression time of pain,inflammation,and redness in the observation group was shorter than that in the control group(P<0.05).After 24 hours of treatment,the levels of SOD and GSH-Px in the observation group were higher than those in the control group(P<0.05).Conclusion Self-made traditional Chinese medicine prescription combined with far infrared therapeutic instrument has good effect on exudation or exudation,and its mechanism may be related to improving serum SOD and GSH-Px.
作者
李娜
李楠
魏学燕
史军然
王敬君
周秀敏
刘彦霞
LI Na;LI Nan;WEI Xueyan;SHI Junran;WANG Jingjun;ZHOU Xiumin;LIU Yanxia(Second Department of Pediatrics,Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang,Hebei 050006,China)
出处
《中华全科医学》
2023年第7期1172-1174,1242,共4页
Chinese Journal of General Practice
基金
河北省中医药管理局2020年度中医药类科研计划课题(2020287)。
关键词
自拟中药方剂
静脉炎
药物外渗
乳香
外敷
Self-made Chinese medicine prescription
Phlebitis
Drug extravasation
Frankincense
External application
