摘要
近视已成为影响我国国民尤其是青少年眼健康的重大公共卫生问题,被列为世界三大疾病之一。近视的病因复杂,目前认为主要与环境因素和遗传因素相关。饮食因素较少被关注,但已有文献报道,高糖饮食与近视发生发展之间存在相关性。研究发现,高糖饮食可引起高胰岛素血症,从而介导视网膜胰岛素样生长因子(IGF-1、IGF-2)表达水平升高,巩膜成纤维细胞中胰岛素样生长因子结合蛋白-3(IGFBP-3)表达水平降低,从而激活信号转导及转录激活蛋白3(STAT3)信号通路,再作用于巩膜基质金属蛋白酶(MMP)/转化生长因子-β(TGF-β)等因子,导致巩膜细胞外基质(ECM)减少,最终导致巩膜重塑眼轴增长而发生近视。本文通过查阅相关文献,从流行病学及生物学机制方面探讨高糖饮食与近视发生发展的关系,为近视防控提供研究方向。
Myopia has become a major public health problem affecting the eye health of our nationals,especially adolescents,and is listed as one of the three major diseases in the world.The etiology of myopia is complex and it is currently considered to be mainly related to environmental factors and genetic factors.Dietary factors are less concerned,but it has been reported that there is a correlation between high-sugar diet and the occurrence and development of myopia.Studies have found that high-sugar diet can cause hyperinsulinemia,which mediates the increase of retinal insulin-like growth factor(IGF-1,IGF-2)expression level,and the decrease of insulin-like growth factor binding protein-3(IGFBP-3)expression level in scleral fibroblasts,thereby activating signal transduction and transcriptional activator protein 3(STAT3)signaling pathway,and then acting on scleral matrix metalloproteinases(MMP)/transforming growth factor-β(TGF-β)and other factors,resulting in a decrease in scleral extracellular matrix(ECM),eventually leading to scleral remodeling,eye axis growth and myopia.This article explores the relationship between high-sugar diet and the occurrence and development of myopia from the aspects of epidemiology and biological mechanisms by consulting relevant literature,and provides research directions for the prevention and control of myopia.
作者
王轶凡
张莲
解孝锋
毕宏生
Yi-Fan Wang;Lian Zhang;Xiao-Feng Xie;Hong-Sheng Bi(Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China;Ophthalmic Hospital Affiliated to Shandong University of Traditional Chinese Medicine,Institute of Ophthalmology Disease Prevention and Control of Shandong,Jinan 250002,Shandong Province,China;Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong,Eye Institute of Shandong University of Traditional Chinese Medicine,Jinan 250002,Shandong Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2023年第8期1333-1337,共5页
International Eye Science
关键词
高糖饮食
近视
青少年
近视发生
近视发展
high-sugar diet
myopia
adolescent
occurrence of myopia
development of myopia
