摘要
DJ-1是PARK7基因编码的蛋白,属于肽酶C56蛋白质家族,PARK7基因的缺陷会导致常染色体隐性遗传早发性帕金森症。DJ-1蛋白是一个多功能蛋白,它可以作为一个积极的雄激素受体介导的转录调节子,也可以用作氧化还原敏感的分子伴侣,氧化应激传感器,还可以保护神经元免于氧化应激和细胞死亡。此外,DJ-1还与线粒体自噬、能量代谢、线粒体稳态、内质网-线粒体结构偶联等生命过程有关。然而目前,DJ-1蛋白的精确功能尚不是很清楚。该文对DJ-1蛋白调控线粒体功能的作用、机制、分子基础展开综述,并结合临床疾病探讨其潜在价值,具有较好的时效性、必要性、创新性和科学性,也有助于为临床药物开发提供新的靶点和思路。
Dj-1 is a protein encoded by PARK7 gene,a member of the peptidase C56 protein family.Defects in PARK7 gene may lead to autosomal recessive early-onset Parkinson’s disease.Dj-1 is a multifunctional protein that acts as an active androgen receptor-mediated transcriptional regulator,a REDOX sensitive molecular chaperone,an oxidative stress sensor,and it also protects neurons from oxidative stress and cell death.In addition,DJ-1 is also associated with mitochondria,energy metabolism,mitochondrial homeostasis,mitophagy mitochondria-associated endoplasmic reticulum membranes and other life processes.However,the precise function of DJ-1 protein is not well understood.This paper reviews the effect,mechanism and molecular basis of DJ-1 protein in regulating mitochondrial function,and discusses its potential value in combination with clinical diseases.It has good timeliness,necessity,innovation and science,and also helps to provide new targets and ideas for clinical drug development.
作者
倪晓晨
于世龙
刘延庆
金凤
NI Xiao-chen;YU Shi-long;LIU Yan-qing;JIN Feng(The State Administration of Traditional Chinese Medicine Key Laboratory of Toxic Pathogens-Based Therapeutic Approaches of Gastric Cancer,College of Medicine,Yangzhou University;Yangzhou Hospital of Traditional Chinese Medicine;Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu 225009,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第8期1406-1411,共6页
Chinese Pharmacological Bulletin
基金
国家自然科学基金青年基金项目(No 81903850),江苏省中医药科技发展计划项目(No YB201992)。
关键词
DJ-1
线粒体
氧化应激
线粒体自噬
内质网-线粒体结构偶联
钙信号
DJ-1
mitochondria
oxidative stress
mitophagy
mitochondria-associated endoplasmic reticulum membranes
calcium signal
