摘要
肝细胞癌(hepatocellular carcinoma, HCC)是消化系统常见的恶性肿瘤,目前HCC的诊断和治疗仍是一大难题。微小RNA(microRNA,miRNA)是基因表达中关键的调控因子,在癌细胞的基因表达和调控中发挥重要的作用,近年来研究发现,HCC中也存在着特异性的miRNA表达,通过调控这些miRNA的表达,可以进一步调控癌细胞的增殖、凋亡、侵袭和迁移等,并且miRNA可能是HCC的诊断和治疗的潜在生物学标志物和治疗靶点。另外,中药有效成分中也存在miRNA表达,有望通过提取中药有效成分应用于HCC的治疗。通过总结相关文献,阐述近年来miRNA联合中医药肝细胞癌诊治中的研究进展。
Hepatocellular carcinoma(HCC)is a common malignant tumor of the digestive system.At present,the diagnosis and treatment of HCC is still a big problem.MicroRNA(miRNA)is a key regulator of gene expression and plays an important role in gene expression and regulation of cancer cells.Recent studies have found that specific miRNA expression also exists in HCC.By regulating the expression of the miRNA,it can further regulate the proliferation,apoptosis,invasion and migration of cancer cells,and miRNA may be a potential biomarker and therapeutic target for the diagnosis and treatment of HCC.In addition,miRNA is also expressed in the active ingredients of traditional Chinese medicine,which is expected to be used in the treatment of HCC by extracting the active ingredients of traditional Chinese medicine.In this paper,the research progress of miRNA combined with traditional Chinese medicine in the diagnosis and treatment of hepatocellular carcinoma in recent years was reviewed by referring to relevant literatures.
作者
杨贻铃
邓鑫
YANG Yiling;DENG Xin(Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;Ruikang Hospital Affiliated to Guangxi University of Chinese,Nanning 530001,Guangxi,China)
出处
《中华中医药学刊》
CAS
北大核心
2023年第7期203-207,共5页
Chinese Archives of Traditional Chinese Medicine
基金
国家自然科学基金项目(81860790)
广西科技计划项目(桂科AB20297002)
广西自然科学基金项目(2020GXNSFAA297160)
广西一流学科中西医结合培育学科项目(2019XK159)
广西特聘专家专项(桂人才通字[2019]13号)
广西中医药大学研究生教育创新计划项目(YCBXJ2021020)
广西中医药大学桂派中医药传承创新团队基金项目(2022B1004)。
关键词
肝细胞癌
MICRORNA
中医药
hepatocellular carcinoma
microRNA
traditional Chinese medicine
