摘要
目的:探讨小金胶囊联合硒酵母片治疗桥本甲状腺炎合并甲状腺结节的临床疗效。方法:选取2021年9月—2022年9月就诊于安徽中医药大学第一附属医院80例甲状腺功能正常的桥本甲状腺炎合并甲状腺结节患者作为观察对象,按照1:1的比例将80例患者随机分为观察组(n=40)和对照组(n=40)。对照组患者口服硒酵母片2片/次,2次/d,治疗组在对照组的基础上另予以口服小金胶囊4粒/次,2次/d,服药时间共计12周。结果:治疗组与对照组甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)、甲状腺最大结节的最长直径比较差异有统计学意义(P<0.05);2组患者甲状腺功能无明显变化;观察组总有效率为80%(32/40)显著高于对照组52.5%(21/40),差异有统计学意义(P<0.05)。结论:小金胶囊联合硒酵母片可使甲状腺功能正常的桥本甲状腺炎合并甲状腺结节患者的临床症状得到明显缓解,患者的血清TPOAb、TGAb水平明显下降,缩小甲状腺结节,疗效确切,且安全性高。
Objective:To explore the clinical efficacy of Xiaojin Capsules combined with Selenium Yeast Tablets in the treatment of Hashimoto’s thyroiditis complicated with thyroid nodules.Methods:From September 2021 to September 2022,80 patients with normal thyroid function and Hashimoto’s thyroiditis complicated with thyroid nodules who visited the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine were selected as observation objects.Patients were randomly divided into observation group(n=40)and control group(n=40).The patients in the control group took 2 selenium yeast tablets orally,2 times a day,and the treatment group also took 4 Xiaojin capsules orally,2 times a day,on the basis of the control group,for a total of 12 weeks.Results:There were significant differences in thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb),and the longest diameter of the largest thyroid nodule between the treatment group and the control group(P<0.05);There was no significant change;the total effective rate in the observation group was 80%(32/40),which was significantly higher than that in the control group(52.5%(21/40),the difference was statistically significant(P<0.05).Conclusion:Xiaojin Capsules combined with Selenium Yeast Tablets can significantly relieve the clinical symptoms of patients with Hashimoto’s thyroiditis complicated with thyroid nodules with normal thyroid function,the serum TPOAb and TGAb levels of the patients can be significantly reduced,and the thyroid nodules can be reduced.The curative effect is exact and safe.high sex.
作者
周鑫鑫
朱梦燕
尹样样
张银玉
方朝晖
ZHOU Xinxin;ZHU Mengyan;YIN Yangyang;ZHANG Yinyu;FANG Zhaohui(Anhui University of Chinese Medicine,Anhui Hefei 230031,China;The First Affiliated Hospital of Anhui University of Chinese Medicine,Anhui Hefei 230031,China;Xin’an Key Laboratory of Medical Science,Ministry of Education of Anhui University of Chinese Medicine,Anhui Hefei 230031,China)
出处
《中医药临床杂志》
2023年第7期1390-1393,共4页
Clinical Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81774286,81603574,81573944,82174153)
国家中医临床研究基地业务建设第二批科研专项(JDZX2015123)
国家重点研发计划“战略性国际科技创新合作”重点专项(2020YFE0201800)
国家重点研发计划“中医药现代化研究”重点专项(2018YFC1704202,2019YFC1709203-4)
安徽省高校自然科学研究重点项目(KJ2020A0383)
安徽省自然科学基金(1708085QH213)
安徽省高校协同创新项目(GXXT-2020-025)
第五批省“特支计划”人才项目(dwps“tzjh”rcxm20190028)
安徽省中医药领军人才及培养对象项目(2019ahszyyljrcxm20190027)
方朝晖安徽省名中医工作室(2019-8-515)
安徽中医药大学2020年自然科学研究重点项目(2020yfyzc24)
2020年安徽省教学质量工程项目(2020xsjxms135)
2021年安徽中医药大学纵向探索性科研项目(2021zxts57)
新安医学教育部重点实验室(安徽中医药大学)。
关键词
小金胶囊
硒酵母片
桥本甲状腺炎
甲状腺结节
临床观察
Xiaojin capsule
Selenium yeast tablet
Hashimoto’s thyroiditis
Thyroid nodule
Clinical observation
