摘要
目的:观察胰高血糖素样肽-1受体激动剂司美格鲁肽对合并2型糖尿病的冠心病并已行冠状动脉旁路移植(coronary artery bypass grafting,CABG)术后患者血糖的影响。方法:选择2022年2月至2022年6月,于北京安贞医院起始司美格鲁肽治疗,合并2型糖尿病的冠心病并已行CABG术的患者作为研究对象,选择同期就诊未应用司美格鲁肽的患者做为对照组,观察24周,比较治疗前后HbA1c、FBG、体质量、血压、血脂的变化。结果:基线时两组患者临床情况差异无统计学意义,观察组平均HbA1c(8.6±1.1)%,平均体质量(82.2±11.3)kg。24周时,观察组HbA1c下降0.9%,体质量减轻4.2kg,收缩压降低4.3mmHg(1mmHg=0.133kPa,P<0.05),舒张压、血脂也有改善趋势;对照组FGB、体质量有改善趋势,但差异无统计学意义。结论:司美格鲁肽显著改善合并2型糖尿病的冠心病并已行CABG术后患者的血糖、体重和收缩压。
Objective:To observe the efficacy of semaglutide,a glucagon-like peptide-1 receptor agonist,in patients with type 2 diabetes complicated with coronary heart disease and coronary artery bypass grafting(CABG).Methods:From February 2022 to June 2022,patients with coronary heart disease complicated with type 2 diabetes and CABG were selected as the study subjects,The control group was selected from the patients who did not receive semaglutide during the same period,The observation period was 24 weeks.The changes of HbA1c,fasting blood glucose,body weight,blood pressure and blood lipid before and after treatment were observed.Result:At baseline,there was no significant difference between the two groups.Patients of observation group had a mean HbA1c of(8.6±1.1)%and a mean body weight of(82.2±11.3)kg.After 24 weeks of treatment,in observation group,HbA1c decreased by 0.9%,body weight decreased by 4.2 kg and systolic blood pressure decreased by 4.3mmHg(P<0.05),Diastolic blood pressure and blood lipid showed a trend of improvement also.The blood glucose and body weight of the control group showed a trend of improvement,but there was no statistical difference.Conclusions:Semaglutide significantly improved blood glucose,body weight and systolic blood pressure in patients with type 2 diabetes complicated with coronary heart disease and CABG.
作者
张凤丽
李宇
赵一楠
文丽娜
陶红
ZHANG Fengli;LI Yu;ZHAO Yinan;WEN Lina;TAO Hong(Department of Endocrinology,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)
出处
《心肺血管病杂志》
CAS
2023年第7期679-682,692,共5页
Journal of Cardiovascular and Pulmonary Diseases
基金
首都卫生发展科研专项(2014-2-1054)
中华国际医学交流基金会-国际糖尿病交流与实践专项基金森美中华糖尿病科研(Z2017-26-1902-4)。
