摘要
目的探讨补阳还五汤加减联合高压氧治疗脑卒中后遗症的临床效果。方法选择2019年3月至2021年3月在本院接受治疗的96例脑卒中后遗症患者为研究对象,将其随机分为对照组和研究组,各48例。对照组给予高压氧治疗,研究组在对照组基础上给予补阳还五汤加减治疗。比较两组的治疗效果。结果治疗后,研究组的γ-氨基丁酸(GABA)水平高于对照组,谷氨酸水平低于对照组(P<0.05)。治疗后,研究组的血浆黏度和纤维蛋白原(FIB)水平低于对照组(P<0.05)。治疗后,研究组的血管性血友病因子(vWF)及内皮素-1(ET-1)水平低于对照组,内皮型一氧化氮合酶(eNOS)水平高于对照组(P<0.05)。治疗后,研究组的肢体麻木、半身不遂、头晕目眩和语言謇涩评分低于对照组(P<0.05)。研究组的临床治疗效果优于对照组(P<0.05)。结论补阳还五汤加减联合高压氧有助于纠正脑卒中后遗症患者的神经递质水平,改善血流状态和血管内皮功能。
Objective To explore the clinical effect of modified Buyang Huanwu decoction combined with hyperbaric oxygen in the treatment of stroke sequelae.Methods A total of 96 patients with stroke sequelae treated in our hospital from March 2019 to March 2021 were selected as the research objects and randomly divided into control group and study group,with 48 cases in each group.The control group was treated with hyperbaric oxygen,and the study group was treated with modified Buyang Huanwu decoction on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the level ofγ-aminobutyric acid(GABA)in the study group was higher than that in the control group,and the level of glutamic acid was lower than that in the control group(P<0.05).After treatment,the plasma viscosity and fibrinogen(FIB)level in the study group were lower than those in the control group(P<0.05).After treatment,the levels of von Willebrand factor(vWF)and endothelin-1(ET-1)in the study group were lower than those in the control group,and the level of endothelial nitric oxide synthase(eNOS)was higher than that in the control group(P<0.05).After treatment,the scores of limb numbness,hemiplegia,dizziness and language astringency in the study group were lower than those in the control group(P<0.05).The clinical effect of treatment of the study group was better than that of the control group(P<0.05).Conclusion Modified Buyang Huanwu decoction combined with hyperbaric oxygen can help to correct the level of neurotransmitters in patients with stroke sequelae,improve the blood flow status and vascular endothelial function.
作者
张建平
李涛
王文
石敏
刘敏良
路强
ZHANG Jianping;LI Tao;WANG Wen;SHI Min;LIU Minliang;LU Qiang(No.2 Encephalopathy Department,Shangluo Traditional Chinese Medicine Hospital,Shangluo 726000,China)
出处
《临床医学研究与实践》
2023年第23期113-116,共4页
Clinical Research and Practice
关键词
脑卒中
后遗症
高压氧
补阳还五汤
stroke
sequelae
hyperbaric oxygen
modified Buyang Huanwu decoction
