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阿德福韦酯导致低磷骨软化症并Fanconi综合征1例 被引量:1

A case of hypophosphatemic osteomalacia with secondary Fanconi syndrome induced by adefovir dipivoxil
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摘要 报道1例以慢性胸背痛为表现的低磷骨软化症并Fanconi综合征患者。患者入院血生化检查结果提示低磷血症、碱性磷酸酶升高;尿常规提示肾性糖尿、蛋白尿及碱性尿,尿磷排出增多;骨密度检查提示骨质疏松;胸椎MRI提示胸6、7假骨折线。患者患有乙型肝炎并有服用阿德福韦酯史。诊断为阿德福韦酯引起的低磷骨软化症、获得性Fanconi综合征。改用恩替卡韦抗病毒治疗,并加用钙尔奇D、阿法骨化醇、甘油磷酸钠等纠正钙磷代谢紊乱,患者症状改善,生化指标及骨密度改善。社区就诊的慢性胸背痛患者以常见病、多发病为主,但不能忽视少见病、罕见病,对于难以明确诊断的患者,应及时转诊至上级医院,以免贻误诊断和治疗。
作者 郭李炜 李雪琴 卢正红 汪丽 陈丹翔 Guo Liwei;Li Xueqin;Lu Zhenghong;Wang Li;Chen Danxiang(Department of General Practice,Affiliated Huai′an No.1 People′s Hospital of Nanjing Medical University,Huai′an 223300,China)
出处 《中华全科医师杂志》 2023年第8期864-866,共3页 Chinese Journal of General Practitioners
基金 南京医科大学附属淮安第一医院2021年度院级教育研究课题(hyyjy2021004)
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