摘要
近年来高脂血症性胰腺炎(hyperlipidemic pancreatitis,HLP)日渐增多,且具有年轻化、重症化、预后差等特点,其发病机制主要包括游离脂肪酸(free fatty acids,FFA)、钙超载、微循环障碍、氧化应激、炎症介质-细胞因子损伤、细胞信号转导通路以及基因多态性等几方面,具有多样性、复杂性,且各作用机制相互联系,本文就近几年其国内外相关研究进展做一综述,以期为后续临床治疗提供思路。
Hyperlipidemic pancreatitis(HLP)has been increasing in recent years and is characterized by younger age,more se-vere disease and poor prognosis.The pathogenesis mainly includes free fatty acids,calcium overload,impaired microcirculation,oxi-dative stress,inflammatory mediator-cytokine damage,cellular signal transduction pathways and genetic polymorphisms,which are diverse and complex,and the mechanisms of action are interconnected.This article reviews the relevant research progress in recent years at home and abroad,with a view to providing ideas for subsequent clinical treatment.
作者
李丽飞
向茜
Li Lifei;Xiang Qian(Department of Endocrinology,The Fifth Affiliated Hospital of Kunming Medical University(South Yunnan Central Hospital,Honghe Prefecture),Ge-jiu,Yunnan,661000,China)
出处
《黑龙江医学》
2023年第15期1913-1915,共3页
Heilongjiang Medical Journal
基金
2020年云南省高层次人才培养万人计划“名医”专项(YNWR-MY-2020-008)
2018年云南省卫生健康委医学学科带头人(内分泌学)培养计划项目(D-2018034)。
关键词
高脂血症
胰腺炎
高脂血症性胰腺炎
发病机制
Hyperlipidemias
Pancreatitis
Hyperlipidemic pancreatitis
Pathogenesis
