摘要
目的分析非小细胞肺癌(NSCLC)疾病特点,评价克唑替尼联合沙利度胺治疗的效果。方法86例NSCLC患者,采取随机数字表法分为对照组与观察组,各43例。对照组患者采取克唑替尼治疗,观察组患者在对照组基础上联合沙利度胺治疗。比较两组患者治疗效果、不良反应发生情况及肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)水平。结果观察组患者治疗总有效率46.51%及临床控制率79.07%均高于对照组的23.26%、48.84%,差异具有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。观察组患者TNF-α、VEGF、bFGF水平分别为(10.45±2.99)、(384.59±70.50)、(8.65±2.45)pg/ml,低于对照组的(17.35±4.05)、(488.33±70.50)、(14.50±2.60)pg/ml,差异具有统计学意义(P<0.05)。结论克唑替尼联合沙利度胺治疗NSCLC具有安全性、有效性价值,有助于抑制肿瘤发展、转移。
Objective To analyze the characteristics of non-small cell lung cancer(NSCLC)and evaluate the effect of combined treatment with crizotinib and thalidomide.Methods A total of 86 patients with NSCLC were randomly divided into control group and observation group,with 43 cases in each group.The control group was treated with crizotinib,and the observation group was treated with thalidomide on the basis of control group.Both groups were compared in terms of therapeutic effect,occurrence of adverse reactions and levels of tumor necrosis factor-α(TNF-α),vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF).Results The total effective rate of 46.51%and the clinical control rate of 79.07%in the observation group were higher than those of 23.26%and 48.84%in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).The levels of TNF-α,VEGF and bFGF in the observation group were(10.45±2.99),(384.59±70.50)and(8.65±2.45)pg/ml,which were lower than those of(17.35±4.05),(488.33±70.50)and(14.50±2.60)pg/ml in the control group,and the differences were statistically significant(P<0.05).Conclusion Crizotinib combined with thalidomide has a safe and effective value in the treatment of NSCLC,which can help inhibit tumor development and metastasis.
作者
韩晓明
HAN Xiao-ming(Department of Oncology,Lingyuan Central Hospital,Lingyuan 122500,China)
出处
《中国现代药物应用》
2023年第14期113-115,共3页
Chinese Journal of Modern Drug Application
