摘要
目的:通过分析滑膜炎、痤疮、脓疱病、骨肥厚、骨髓炎(Synovitis-acne-pustulosis-hyperostosis-osteomyelitis Syndrome,SAPHO)综合征患者的临床特点,初步探索辨证分型规律。方法:采用回顾性研究方法收集符合标准的SAPHO综合征患者41例,记录一般情况、辅助检查及活动性评分等临床资料,进行中医辨证分型,并进行数据分析。结果:41例患者中,有湿热痹阻证患者21例(51.22%),肝肾亏虚证患者12例(29.27%),寒湿痹阻证患者8例(19.51%)。65.85%的病例在2年内相继出现皮损及骨关节表现;各证型在病程、发病与诊断年龄、皮损与骨关节发病情况等方面的差异有统计学意义。结论:SAPHO综合征患者以青年女性居多。其中湿热痹阻证型病程短、发病早、诊断早,肝肾亏虚证型病程长,发病及确诊晚;有一定季节性。皮损和骨关节发病顺序对中医辨证分型有一定参考意义。SAPHO为罕见病,病例数少,临床表现特异性不高,目前对其认识仍然不足,中医辨证分型方面的研究更少,有一定局限性,后期还需做更深一步的探索,进一步寻找该病的中医病证规律,为其辨证分型提供更多临床证据。
Objective:To preliminarily explore the pattern of TCM syndrome differentiation by analyzing the clinical characteristics of SAPHO syndrome patients.Methods:A retrospective study was conducted to collect 41 SAPHO syndrome patients who met the criteria.The clinical data such as general situation,auxiliary examination,and activity score was recored,and the TCM syndrome differentiation typing and data analysis was performed.Results:Among the 41 patients,there were 21 patients(51.22%)with the dampness-heat obstruction syndrome,12 patients(29.27%)with the liver-kidney deficiency syndrome,and 8 patients(19.51%)with the cold-dampness obstruction syndrome.A total of 65.85%of the patients had skin lesions and bone and joint manifestations within 2 years.There were statistically significant differences in the course of disease,the age of onset and diagnosis,the incidence of skin lesion and bone joint disease among various syndrome types.Conclusion:SAPHO syndrome patients are mainly young women.The dampness-heat obstruction syndrome has short course,early onset and early diagnosis.The liver and kidney deficiency syndrome has long course,late onset and diagnosis time.This disease has a certain seasonality.The incidence sequence of skin lesions and bone joint diseases has a certain reference significance for TCM syndrome differentiation and classification.SAPHO is a rare disease with a small number of cases and low specificity of clinical manifestations.The current understanding of the disease is still insufficient,and there are fewer studies on TCM syndrome differentiation and classification,which has certain limitations.Further exploration is needed in the later stage to further search for the TCM syndrome regularity of the disease,and provide more clinical evidence for its differentiation and classification.
出处
《中医临床研究》
2023年第19期26-30,共5页
Clinical Journal Of Chinese Medicine
