摘要
目的探讨结肠癌患者的血清HMGB1和SAA水平及其与预后的关系。方法60例结肠癌患者根据12个月内的预后情况分为死亡组(n=16)、生存组(n=44),检测两组的HMGB1及SAA水平,分析二者与预后的关系。结果单因素及多因素Logistic回归分析显示,淋巴结转移、HMGB1、SAA为结肠癌患者预后的独立影响因素(P<0.05)。ROC曲线分析显示,HMGB1、SAA联合检测预测结肠癌患者预后的AUC为0.901,高于HMGB1的0.750、SAA的0.766(P<0.05)。结论血清HMGB1、SAA与结肠癌患者预后关系密切,检测二者水平有助于早期评估预后情况。
Objective To explore the serum HMGB1 and SAA levels in patients with colon cancer and their relationships with prognosis.Methods According to the prognosis within 12 months,60 patients with colon cancer were divided into death group(n=16)and survival group(n=44).The levels of HMGB1 and SAA in the two groups were detected,and the relationships between them and prognosis were analyzed.Results Univariate analysis and multivariate Logistic regression analysis showed that lymph node metastasis,HMGB1 and SAA were independent factors affecting the prognosis of patients with colon cancer(P<0.05).ROC curve analysis showed that the AUC of combined detection of HMGB1 and SAA in predicting the prognosis of patients with colon cancer was 0.901,higher than 0.750 of HMGB1 and 0.766 of SAA(P<0.05).Conclusions Serum HMGB1 and SAA are closely related to the prognosis of patients with colon cancer,and the detection of the two levels is helpful for early evaluation of prognosis.
作者
张永珍
王珊珊
陈瑜
ZHANG Yongzhen;WANG Shanshan;CHEN Yu(Clinical Laboratory,Xinxiang Central Hospital,Xinxiang 453000,China)
出处
《临床医学工程》
2023年第8期1173-1174,共2页
Clinical Medicine & Engineering
