摘要
目的 分析氟替美维吸入粉雾剂对慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)患者的影响。方法 选取2021年1月—2022年10月于江苏省句容市人民医院就诊的患者86例为研究对象,依据治疗方式分为两组,对照组42例,研究组44例。对照组予布地奈德福莫特罗吸入粉雾剂联合乙酰半胱氨酸泡腾片与孟鲁司特钠片治疗,研究组则予以氟替美维联合乙酰半胱氨酸泡腾片和孟鲁司特钠片,评估两组临床有效率、各项临床指标、6 min步行距离以及肺功能指标。结果 研究组临床有效率(97.73%)高于对照组(80.95%),差异有统计学意义(χ^(2)=4.787,P<0.05)。研究组临床症状评分与呼吸困难评分低于对照组,运动耐力评分与生活质量评分高于对照组,差异有统计学意义(P<0.05)。治疗后研究组6 min步行距离长于对照组,差异有统计学意义(P<0.05)。治疗后研究组FVC、FEV1与PEF指标均高于对照组,差异有统计学意义(P<0.05)。结论 氟替美维吸入粉雾剂在实际应用期间可以有效改善慢性阻塞性肺疾病患者肺功能,提升患者的运动耐受力,以及提高患者的生活质量,从而能够促进患者尽快恢复。
Objective To investigate the effects of flutemeivir inhalation powder aerosol on chronic obstructive pulmo‐nary disease(COPD).Methods 86 patients who visited the People's Hospital of Jurong City,Jiangsu Province from January 2021 to October 2022 were selected as the research subjects.They were divided into two groups based on treatment methods a control group of 42 cases and a study group of 44 cases.The control group was treated with budesonide formoterol inhalation powder spray combined with acetylcysteine effervescent tablest and montelukast so‐dium tablets,while the study group was treated with flutemevir combined with acetylcysteine effervescent tablets and montelukast sodium tablets.The clinical efficiency,clinical indicators,6-minute walking distance and lung function indicators of the two groups were evaluated.Results The clinical effective rate of the study group(97.73%)was higher than that of the control group(80.95%),the difference was statistically significant(χ^(2)=4.787,P<0.05).The clinical symptom score and dyspnea score of the study group were lower than those of the control group,while the exercise en‐durance score and quality of life score were higher than those of the control group,the difference was statistically sig‐nificant(P<0.05).After treatment,the 6-minute walking distance of the study group was longer than that of the con‐trol group,and the difference was statistically significant(P<0.05).After treatment,the FVC,FEV1,and PEF indica‐tors in the study group were higher than those in the control group,the difference was statistically significant(P<0.05).Conclusion Flutemeivir inhalation powder aerosol can effectively improve the lung function of patients with chronic obstructive pulmonary disease,improve the exercise tolerance of patients,and improve the quality of life of pa‐tients,so as to promote patients to recover as soon as possible.
作者
周长燕
许广丽
黄光银
ZHOU Changyan;XU Guangi;HUANG Guangyin(Department of Pharmacy,Jurong People's Hospital,Jurong,Jiangsu Province,212400 China;Department of Clini‐cal Respiratory,Jurong People's Hospital,Jurong,Jiangsu Province,212400 China)
出处
《系统医学》
2023年第10期181-185,共5页
Systems Medicine
关键词
氟替美维吸入粉雾剂
慢性阻塞性肺疾病
运动耐力
肺功能指标
6MIN步行距离
呼吸困难
Flutemeivir inhalation powder aerosol
Chronic obstructive pulmonary disease
Sports endurance
Pulmonary function index
6min walking distance
Dyspnea
