摘要
目的了解云南省北部地区6~12岁儿童棘球蚴病血清抗体水平。方法按照《全国包虫病流行病学调查方案》,于2013-2017年对迪庆、大理等9个州(市)的德钦、香格里拉、维西、洱源等28个县(市、区)采用分层抽样的方法抽取87所小学,对6~12岁儿童采集血样,采用ELISA法检测棘球蚴IgG抗体,组间血清抗体阳性率比较采用χ^(2)检验。结果共检测6~12岁儿童13913人,血清抗体阳性236人,阳性率为1.7%。9个州(市)中以迪庆州阳性率最高,为2.22%(92/4134);曲靖市阳性率最低,为0.64%(4/625)。28个县(市、区)中以剑川县阳性率最高,为3.18%(8/251);贡山县阳性率最低,为0.28%(1/349)。不同地州之间阳性率差异有统计学意义(χ^(2)=21.42,P<0.05)。男性儿童阳性率为2.01%(143/7109),女性儿童为1.37%(93/6804),差异有统计学意义(χ^(2)=8.54,P<0.01)。按年龄分组,以12岁组阳性率最高,为2.43%(85/3491);6岁组最低,为0.68%(3/436)。不同年龄组间阳性率差异无统计学意义(χ^(2)=11.91,P>0.05)。按调查地区生产方式分组,阳性率由高至低依次为:牧区2.41%(76/3149),半农半牧区1.93%(128/6629),农区0.77%(32/4135),差异有统计学意义(χ^(2)=33.11,P<0.01)。半农半牧区男女儿童阳性率分别为2.43%和1.42%,差异有统计学意义(χ^(2)=8.91,P<0.01)。藏族、白族、傈僳族、纳西族、彝族、汉族6个民族儿童占总调查儿童人数的96.56%(13435/13913),且主要聚集在滇西北地区,其中以牧区藏族儿童血清抗体阳性率较高,为2.6%(51/1960);其次为半农半牧区的白族儿童,为2.11%(58/2749),傈僳族1.82%(53/2879),纳西族1.68%(12/713),彝族1.46%(25/1708)。不同民族儿童阳性率差异有统计学意义(χ^(2)=22.87,P<0.01)。结论云南省北部地区儿童棘球蚴病血清抗体阳性率处于较低水平,但局部地区尚高,因此应进一步加强对当地儿童的健康教育并采取相应的防治措施,从而降低儿童感染包虫病的风险。
Objective To understand the serum antibody levels of hydatid disease in children aged 6-12 years in the northern region of Yunnan Province.Methods Based on the national hydatid disease epidemiological investigation progarm,Children aged 6 to 12 years in 87 primary schools selected by stratified sampling were made in Deqin County,Shangri-La City,Weixi County,Eryuan County and other 28 counties(cities,districts)in Diqing regions,Dali regions and other 9 regions/cities)in northern Yunnan Province 2013 to 2017.The serum level of anti echinococcus IgG were determined by ELISA.Sero-positive rate of anti-echinococcosis antibody between groups were analyzed withχ^(2)test.Results A total of 13913 children were examined,and 236(1.7%)were positive for anti-echinococcus IgG.Among the regions of survey,the sero-positive rate was highest in Diqing regions(2.22%,92/4134),and lowest in Qujing City(0.64%,4/625).Among the counties of survey,the sero-positive rate was highest in Jian chuan County(3.18%,8/251),and lowest in Gong shan City(0.28%,1/349),Different sero-positive rates were observed in different regions/counties,which is statistically significant(χ^(2)=21.42,P<0.05).The sero-positive rate of male children was 2.01%(143/7109),and that of female children was 1.37%(93/6804),Different sero-positive rates were observed in different sex,which is statistically significant(χ^(2)=8.54,P<0.01).Among different age groups,the sero-positive rate was highest in the group of 12 years(2.43%,85/3491),and lowest in 6 year group(0.68%,3/436),Different sero-positive rates were observed in different age groups,which is no statistically significant(χ^(2)=11.91,P>0.05).Group groups by production mode in the survey area,The sero-positive rate was from high to low in order:2.41%(76/3149)in pastoral areas,1.93%(128/6629)in semi-agricultural and semi-pastoral areas,0.77%(32/4135)in agricultural areas,Different sero-positive rates were observed in different production modes,which is statistically significant(χ^(2)=33.11,P<0.01).The sero-positive rate of male and female children in semi-agricultural and semi-pastoral areas was 2.43%and 1.42%,The difference is statistically significant(χ^(2)=8.91,P<0.01).Tibetan,Bai,Lisu,Naxi,Yi and Han nationalities accounted for 96.56%(13435/13913)of the total number of children surveyed,and mainly concentrated in northwest Yunnan,the highest sero-positive rate of Tibetan children in pastoral areas was 2.6%(51/1960),followed by the Bai 2.11%(58/2749),Lisu 1.82%(53/2879),Naxi 1.68%(12/713)and Yi 1.46%(25/1708),Different sero-positive rates were observed in different nations,which is statistically significant(χ^(2)=22.87,P<0.01).Conclusion The serum antibody positive rate of children in the northern part of Yunnan province is at a low level,but some areas are relatively high.Therefore,health education for local children should be further strengthened and corresponding prevention measures should be taken,so as to reduce the risk of hydatid disease in children.
作者
字金荣
杨亚明
吴方伟
严信留
彭佳
蔡璇
王正青
李建雄
徐倩
史帅
段承丽
李奔福
ZI Jinrong;YANG Yaming;WU Fangwei;YAN Xinliu;PENG Jia;CAI Xuan;WANG Zhengqing;LI Jianxiong;XU Qian;SHI Shuai;DUAN Chengli;LI Benfu(Yunnan Institute of Parasitic Diseases,Yunnan Provincial Collaborative Innovation Center for Public Health and Disease Prevention and Control(YPCICPHDPC),Dial University Institute of Pathogen and Vector Biology(Puer Divistion),Pu'er 665000,Yunnan,China;Diqing Prefecture Center for Disedse Control and Prevention;Nujiang Prefecture Center for Disedse Control and Prevention)
出处
《中国病原生物学杂志》
CSCD
北大核心
2023年第8期939-942,947,共5页
Journal of Pathogen Biology
关键词
棘球蚴病
血清抗体
调查
儿童
云南省
echinococcosis
serum antibody
investigate
children
Yunnan Province
