摘要
目的探讨清热解毒中药灌洗对宫颈癌放射性阴道炎患者中医症候、阴道炎症的影响和安全性。方法按照随机数字表法分配原则将120例2019年5月-2022年5月河北沧州中西医结合医院放化疗二科收治的宫颈癌放射性阴道炎患者分为对照组和试验组,各60例。对照组给予高锰酸钾溶液进行常规阴道冲洗,试验组给予清热解毒中药进行阴道冲洗,2组均持续治疗6个月。比较2组治疗6个月后的疗效,治疗前、治疗6个月后的中医证候、阴道酸碱度值(p H值)、阴道症状、免疫功能、阴道炎症指标水平及治疗期间的安全性。结果与对照组治疗6个月后的总有效率(80.00%)比较,试验组总有效率较高(93.33%,P<0.05)。治疗6个月后,2组外阴瘙痒、干涩灼热、带下量多、色黄味腥臭、阴道清洁度评分、阴道p H值及血清单核细胞趋化蛋白1(MCP-1)、C反应蛋白(CRP)、白细胞介素-13(IL-13)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平与治疗前比较降低,试验组低于对照组(P<0.05);2组阴道局部体征评分及血清免疫球蛋白G(Ig G)、免疫球蛋白A(Ig A)、免疫球蛋白M(Ig M)水平与治疗前比较升高,试验组高于对照组(P<0.05)。试验组治疗期间的不良反应总发生率(5.00%)与对照组(11.67%)比较无差异(P>0.05)。结论清热解毒中药灌洗可有效调节宫颈癌放射性阴道炎患者阴道p H值,改善阴道症状和中医证候,并可减轻患者阴道炎症,改善免疫功能,进而可提高疗效,且具有良好的安全性。
Objective To explore the influence and safety of the traditional Chinese medicine lavage for clearing heat and removing toxicity on the TCM symptoms and vaginitis in patients with radiation vaginitis of cervical cancer.Methods A total of 120 patients with radiation vaginitis of cervical cancer admitted to the Second Department of Radiotherapy and Chemotherapy of the Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from May 2019 to May 2022 were divided into a control group(60 cases)and a test group(60 cases)by the distribution principle of random number table.The control group was given a routine vaginal lavage with the potassium permanganate solution,while the test group was given a vaginal lavage with herbs for clearing heat and removing toxicity,both for 6 months.The curative effect after 6 months of treatment,the scores of the traditional Chinese medicine syndromes,vaginal pH value,vaginal symptoms,immune function,the level of vaginitis index before and after 6 months of treatment and the safety during treatment were compared between the two groups.Results Compared with the total effective rate(80.00%)of the control group,the total effective rate of the test group was higher after 6 months of treatment(93.33%,P<0.05).After 6 months of treatment,the scores of vulvae itching,dryness,burning heat,excessive vaginal discharge,yellow-colored odor,vaginal cleanliness,the vaginal pH value and the serum levels of monocyte chemoattractant protein-1(MCP-1),C-reactive protein(CRP),interleukin-13(IL-13),interleukin-6(IL-6),interleukin-8(IL-8)in the two groups were lower than before treatment,and the levels in the test group were lower than those in the control group(P<0.05).The scores of local vaginal signs and the serum levels of immunoglobulin G(IgG),immunoglobulin A(IgA)and immunoglobulin M(IgM)in the two groups were higher than before treatment,and the test group was higher than the control group(P<0.05).The total incidence of adverse reactions during treatment in the test group(5.00%)was not significantly different from that in the control group(11.67%)(P>0.05).Conclusion The herbal lavage for clearing heat and removing toxicity can effectively regulate the vaginal pH value of patients with radiation vaginitis of cervical cancer,improve the vaginal symptoms,TCM syndromes,and alleviate the vaginitis of patients,improve the immune function,and then improve the curative effect,with a higher safety.
作者
郜蕾
胡建伟
苗珺珺
田丹丹
王晴雯
齐子威
陈媛媛
崔芒芒
侯光营
GAO Lei;HU Jianwei;MIAO Junjun;TIAN Dandan;WANG Qingwen;QI Ziwei;CHEN Yuanyuan;CUI Mangmang;HOU Guangying(Second Department of Radiotherapy and Chemotherapy of Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061000,China)
出处
《吉林中医药》
2023年第8期926-930,共5页
Jilin Journal of Chinese Medicine
基金
河北省中医药管理局科研计划项目(2019304)。
关键词
宫颈癌
放射性阴道炎
清热解毒中药
中医证候
阴道炎症
免疫功能
安全性
cervical cancer
radiation vaginitis
herbs for clearing heat and removing toxicity
traditional Chinese medicine syndrome
vaginitis
immune function
safety
