摘要
牛支原体(M.bovis)是感染牛的一种重要病原体,可导致感染牛出现肺炎、关节炎、乳房炎、角膜结膜炎和生殖道炎等多种临床症状,给养牛业造成了巨大经济损失。M.bovis黏附素在M.bovis致病过程中发挥重要作用,包括病原感染、细胞入侵、免疫逃逸和毒力产生。迄今为止,已鉴定出十多种M.bovis黏附素。这些黏附素主要结合宿主细胞的纤溶酶原(plasminogen,Plg)、纤连蛋白(fibronectin,FN)、硫酸肝素(heparin sulfate,HS)和淀粉样前体样蛋白-2(amyloid precursor-like protein-2,APLP2)。本文将对目前已知的M.bovis黏附素及其宿主细胞靶蛋白的研究现状进行综述,为M.bovis已知和未知黏附素的鉴定和应用提供参考。
Mycoplasma bovis(M.bovis)is an important pathogen that infects cattle,which can lead to a variety of clinical symptoms such as pneumonia,arthritis,mastitis,keratoconjunctivitis and genital tractitis in infected cattle,causing huge economic losses to the cattle industry.M.bovis adhesins play an important role in pathogenesis of M.bovis,including pathogenic infection,cell invasion,immune evasion,and virulence production.So far,more than ten kinds of M.bovis adhesins have been identified.These adhesins primarily bind plasminogen(Plg),fibronectin(FN),heparin sulfate(HS),and amyloid precursor-like protein-2(APLP2)of host cells.This article will review the current research status of M.bovis adhesins and their host cell target proteins,and provide reference for the identification and application of known and unknown adhesins of M.bovis.
作者
武琪
张玉娟
刘桐
辛九庆
徐青元
WU Qi;ZHANG Yujuan;LIU Tong;XIN Jiuqing;XU Qingyuan(State Key Laboratory of Veterinary Biotechnology,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150069,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2023年第8期3206-3216,共11页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然基金面上项目(31872468)。
