摘要
采用19F固体核磁共振技术(19F SS-NMR)对38款含氟牙膏样品中不同形态氟化物进行了分析研究。牙膏样品经少量淀粉混合固化后直接装样采集,采用hahn-echo回波序列,魔角旋转转速12~14 kHz。结果显示,不同摩擦剂与氟化物匹配的稳定性有较大差异,其中摩擦剂水合硅石与氟化物的匹配一般较稳定,氟化物主要以可溶性/游离状态存在于牙膏体系中;部分碳酸钙基质牙膏中,除原料氟化物信号外,还观测到新生成的不可溶性固体氟化钙信号。除摩擦剂的影响外,在一些添加了羟基磷灰石等功效成分的牙膏中,也观测到不可溶性的氟化钙的生成,不可溶性氟化物的生成将降低牙膏中有效氟的含量。对牙膏这种半固体样品,19F SS-NMR具有前处理操作简便、专属性强、灵敏度高等特点,可对含氟牙膏中氟化物进行形态分析,为牙膏配方研发、质量提升提供技术支持。
Different forms of fluoride in 38 fluoride toothpaste samples were determined by 19F solid-state nuclear magnetic resonance(19F SS-NMR).The results show that the matching stability of different friction agents and fluoride is quite different.The soluble and free types are the main forms of fluoride in hydrated silica toothpaste,but newly generated insoluble solid calcium fluoride signal is observed in some calcium carbonate-based toothpastes.In addition to the influence of friction agents,in some toothpastes with functional ingredients such as hydroxyapatite,the formation of insoluble calcium fluoride is also observed.The formation of insoluble fluoride will reduce the amount of available fluoride in toothpaste.19F SS-NMR has the characteristics of simple pretreatment,strong specificity and high sensitivity.It can quickly analyze the morphology of fluoride in fluoride toothpaste,and provide technical support for toothpaste formulation development and quality improvement.
作者
周雷
曹东霞
李家宏
苏哪锋
李文辉
Lei Zhou;Dongxia Cao;Jiahong Li;Nafeng Su;Wenhui Li(Zhongshan Supervision Testing Institute of Quality&Metrology,Zhongshan,Guangdong 528400,China;Hawley&Hazel Chemical Company(Zhongshan)Limited,Zhongshan,Guangdong 528400,China)
出处
《日用化学工业（中英文）》
CAS
北大核心
2023年第8期963-967,共5页
China Surfactant Detergent & Cosmetics
基金
国家市场监督管理总局科技计划项目(2019MK054)。
关键词
牙膏
氟化物
固体核磁共振技术
toothpaste
fluoride
solid state nuclear magnetic resonance technology
