摘要
三阴性乳腺癌(TNBC)是一类治疗困难、预后较差、术后早期易复发且易转移的乳腺癌。发病呈低龄化趋势,种族差异大,具有明显的遗传易感性,因此迫切需要阐明TNBC的遗传风险因素,找到精准的治疗靶点。不同亚型的TNBC之间很难找到可靠的特征性基因及其多态性。为制定有效的TNBC预防策略及找寻有效的治疗靶点,现系统综述近年来与不同亚型TNBC相关的易感基因及其多态性,以期找到可靠的生物标志物,为针对特定分子途径的药物研发提供新的思路。
Triple-negative breast cancer(TNBC)is a type of breast cancer that is difficult to treat,has a poor prognosis,and is prone to recurrence and metastasis in the early postoperative period.The age of patients is tending younger,and the racial difference is large.It is also related to family history,and genetic susceptibility is obvious.So,elucidating the genetic risk factors of TNBC and obtaining precise therapeutic targets are urgent tasks.Obtaining reliable characteristic genes and their polymorphisms between TNBC of different subtypes is difficult.This review summarizes the susceptibility genes and the polymorphisms of TNBC susceptibility genes of different molecular subtypes,in order to develop effective TNBC prevention strategies and find effective therapeutic targets.This review provides a theoretical basis for promoting the study of TNBC from the perspective of genetics.
作者
张丽佳
刘佳芮
张沅
陈薪宇
王信
张怡
ZHANG Lijia;LIU Jiarui;ZHANG Yuan;CHEN Xinyu;WANG Xin;ZHANG Yi(Public Health College,Zunyi Medical University,Zunyi 563000,China;Department of Orthopaedic Surgery,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China)
出处
《肿瘤防治研究》
CAS
2023年第8期794-799,共6页
Cancer Research on Prevention and Treatment
基金
国家自然科学基金(82060620,31960209)。
关键词
三阴性乳腺癌
流行病学
易感基因
遗传多态性
生物标志物
Triple-negative breast cancer
Epidemic profile
Susceptibility genes
Genetic polymorphism
Biomarker
