摘要
目的:仿真模拟无创光疗所用的发光二极管(LED)阵列光源在不同距离下的光斑特征,为临床无创光疗治疗方案的制定提供参考。方法:使用Comsol软件中射线追踪模块进行模拟不同功率和阵列的LED光源在不同距离下的光斑特征,进行拟合曲线分析,以实际LED光斑测定进行模型验证,并以小鼠背部伤口模型验证治疗方案的可行性。结果:在2×2 LED光源阵列下,随着与光源垂直距离的增加,有效区域和治疗区域的面积逐渐增大,区域内功率密度值逐渐降低,均匀性逐渐升高,呈线性或二项式相关。与实际LED光斑对比后改进模型,设计由18颗LED组成的光源阵列,治疗区域显示出较好的均匀性与功率密度值。以模拟的光学参数对小鼠伤口进行光照治疗,可以促进伤口愈合。结论:建立的医用LED阵列光源光斑特征模拟可为临床无创光疗方案的制定提供参考,并根据临床病情需求,选择合适的LED功率和阵列分布,也可为医用LED阵列光源的研发提供依据。
ObjectiveTo simulate the spot characteristics of light emitting diode(LED)array light sources used in non-invasive phototherapy at different distances and to provide reference for the formulation of clinical non-invasive phototherapy treatment schemes.MethodsThe ray tracing module in Comsol software was used to simulate the spot characteristics of LED light sources with different power and arrays at different distances,and the fitting curve was analyzed.The model was verified by the actual LED spot measurement,and the feasibility of the treatment scheme was verified by the mouse back wound model.ResultsUnder the irradiation of 2×2 LED light source array,with the increase of the vertical distance from the light source,the area of the effective area and the treatment area gradually increased,the power density value in the area gradually decreased,and the uniformity gradually increased.These changes showed a linear or binomial correlation with the vertical distance.The model was improved based on the actual LED light spot,and the new model consisted of an array of 18 LEDs as the light source,and the treatment area showed better uniformity and power density values.The simulated optical parameters were used to treat mice’s wounds with light,and the results showed that light treatment could promote wound healing.ConclusionsThe established medical LED array light source spot characteristics simulation can provide a reference for the development of clinical non-invasive phototherapy protocols,thus helping the clinic select the appropriate LED power and array distribution according to the treatment needs and also providing a basis for the development of medical LED array light sources.
作者
张滨滨
崔英健
郑士楠
孙金平
Zhang Binbin;Cui Yingjian;Zheng Shinan;Sun Jinping(School of Stomatology,Tianjin Medical University,Tianjin 300070,China;School of Biomedical Engineering and Technology,Tianjin Medical University,Tianjin 300041,China)
出处
《国际生物医学工程杂志》
CAS
2023年第3期196-204,共9页
International Journal of Biomedical Engineering
基金
天津市教委科研计划项目(2020KJ209)
关键词
LED阵列光源
仿真模拟
无创光疗
LED array light source
Simulation
Non-invasive phototherapy
