摘要
目的分析改良Miccoli术式内镜甲状腺手术治疗对早期分化型甲状腺癌患者的疗效与分析。方法选取早期分化型甲状腺癌患者78例,随机分为研究组和常规组,各组39例。常规组予以传统甲状腺手术,研究组予以改良Miccoli手术。对比两组围术期情况、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)、甲状腺球蛋白抗体(TGAb)、抗甲状腺过氧化物酶抗体(TPOAb)水平、并发症发生率、视觉模拟量表(VAS)评分。结果研究组手术时间、住院时间、切口长度短于常规组,术中出血量少于常规组(P<0.05);术后7 d,研究组CRP、TNF-α、VEGF水平和TGAb、TPOAb水平均低于常规组(P<0.05);研究组并发症发生率低于常规组(P<0.05);术后7 d,研究组VAS评分低于常规组(P<0.05)。结论改良Miccoli术式内镜甲状腺手术治疗早期分化型甲状腺癌患者,可抑制新生血管因子形成,减轻炎性状态,改善甲状腺功能,加快术后恢复,且并发症发生率较低。
Objective To analyze the efficacy and analysis of the modified Miccoli procedure for endoscopic thyroid surgery in patients with early-stage differentiated thyroid cancer.Methods 78 patients with early-stage differentiated thyroid cancer were selected and randomly divided into the study group and the routine group,with 39 cases in each group.The conventional group received traditional thyroid surgery,while the research group received modified Miccoli surgery.Perioperative conditions,levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),vascular endothelial growth factor(VEGF),thyroglobulin antibody(TGAb),anti thyroid peroxidase antibody(TPOAb),and incidence of complications and visual analogue scale(VAS)score between the 2 groups were compared.Results Surgical time,hospitalization time,and incision length of the study group were shorter than those of the conventional group,and the intraoperative bleeding volume was lower than that of the conventional group(P<0.05);7 days after surgery,CRP and TNF in the study group-α、The levels of VEGF,TGAb,and TPOAb were lower than those in the conventional group(P<0.05);The incidence of complications in the study group was lower than that in the conventional group(P<0.05);On the 7th day after surgery,the VAS score of the study group was lower than that of the conventional group(P<0.05).Methods Conclusion:The modified Miccoli procedure for endoscopic thyroid surgery in patients with early differentiated thyroid cancer can inhibit the formation of neovascular factors,alleviate inflammatory status,improve thyroid function,accelerate postoperative recovery,and have a low incidence of complications.
作者
穆慧君
齐宝珍
刘祯
MU Huijun;QI Baozhen;LIU Zhen(The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000)
出处
《实用癌症杂志》
2023年第9期1554-1557,共4页
The Practical Journal of Cancer
