摘要
垂体肿瘤转化基因1(PTTG1)是一种从垂体中分离出来的癌基因。它能结合并抑制分离酶从而影响姐妹染色单体分离导致染色体非整倍体,激活DNA损伤反应途径诱导p53依赖性衰老,还能反式激活一些癌基因进而促进细胞转化与裸鼠成瘤能力。它还能通过影响Wnt/β-catenin、上皮细胞-间充质转化(EMT)、TGFβ/SMAD3通路来促进肿瘤的生长与侵袭。本文为以PTTG1为靶点开发肿瘤治疗药物提供思路。
Pituitary tumor transforming gene 1(PTTG1)is an oncogene which isolated from the pituitary gland.PTTG1 was previously reported to bind and inhibit separase to affect sister chromatid separation and lead to chromosome aneuploidy,activate the DNA damage response pathway to induce p53-dependent senescence,and also transactivate some oncogenes and promote cell transformation and tumorigenesis in nude mice.It can also promote tumor growth and invasion by affecting Wnt/β-catenin,epithelial-mesenchymal transition(EMT),and TGFβ/SMAD3 pathways.This article provides ideas for the development of tumor therapeutic drugs targeting PTTG1.
作者
吴念平
黄惠利
周快乐
周策凡
唐景峰
WU Nianping;HUANG Huili;ZHOU Kuaile;ZHOU Cefan;TANG Jingfeng(Department of Biomedical Sciencese,Institute of Biomedical Research School of Biological Engineering and Food,Hubei University of Technology,Wuhan 430068;National“111”Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University of Technology,Wuhan 430068;Department of Surgery,Guixi People′s Hospital,Guixi 335400,China)
出处
《基础医学与临床》
2023年第9期1448-1452,共5页
Basic and Clinical Medicine
基金
国家自然科学基金(31871176,32070726)。
