摘要
感音神经性耳聋(SNHL)是最常见的听力损失形式,以往主要围绕耳毒性、噪音、老化、自身免疫障碍等原因进而探讨活性氧引起氧化应激损伤或基因变异引起系列分子生物学改变,导致感音神经细胞凋亡,以致听力障碍或丧失。但SNHL的致病机制尚未完全明了,近年来,蛋白质组学技术的飞速发展,为进一步揭示感音神经细胞凋亡相关因子及调控途径提供了新方法、新理论。本文基于蛋白质组学技术在感音神经细胞凋亡途径、机制或治疗靶点等方面的研究进展作一综述,为SNHL的防治提供参考。
Sensorineural hearing loss(SNHL)is the most common form of hearing loss.Previous studies mainly focused on ototoxicity,noise,aging,autoimmune disorders and other causes,exploring oxidative stress damage caused by reactive oxygen species or series of molecular biological changes caused by gene variation,leading to apoptosis of sensorinear nerve cells,resulting in hearing impairment or loss.However,the pathogenic mechanism of SNHL has not been fully understood.In recent years,the rapid development of proteomics technology has provided new methods and theories for further revealing the related factors and regulatory pathways of sensory nerve cell death.This paper reviews the research progress of proteomic techniques in the pathway or mechanism of sensorineural cell death and therapeutic targets,which will provide reference for the prevention and treatment of SNHL.
作者
潘旭
宣伟军
唐俊波
PAN Xu;XUAN Weijun;TANG Junbo(Guangxi University of Traditional Chinese Medicine,Nanning 530200,China;Department of Otorhinolaryngology Head and Neck Surgery,the First Clinical Medical College of Guangxi University of Traditional Chinese Medicine,Nanning 530022,China)
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
CSCD
2023年第4期60-64,共5页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金
国家自然科学基金(81973913、81774374)
研究生教育创新计划项目(YCBXJ2022017)。
关键词
感音神经性耳聋
蛋白质组学
致病机制
治疗靶点
Sensorineural hearing loss
Proteomics
Pathogenic mechanism
Therapeutic target
