摘要
目的比较冷冻联合A型肉毒毒素与单独A型肉毒毒素治疗瘢痕疙瘩的疗效。方法选择2017年4月至2020年4月期间中国人民解放军联勤保障部队第九八一医院收治的瘢痕疙瘩病人98例为该研究对象,按照随机数字表法将其分成两组,对照组49例给予A型肉毒毒素治疗,研究组49例在对照组基础上联合冷冻进行治疗。比较两组疗效、瘢痕厚度、瘢痕面积、痛痒程度、不良反应发生率、复发情况。结果研究组总有效率93.88%(46/49)高于对照组71.43%(35/49)(P<0.05)。治疗后,两组瘢痕厚度、瘢痕面积、痛痒程度均低于治疗前(P<0.05),且治疗后研究组瘢痕厚度、瘢痕面积、痛痒程度低于对照组(P<0.05)。研究组不良反应总发生率12.24%(6/49)与对照组10.20%(5/49)相较,差异无统计学意义(P>0.05)。在完整治疗后为期6个月随访,对照组复发12例,研究组复发8例,研究组复发率16.33%与对照组24.49%相较,差异无统计学意义(P>0.05)。结论冷冻联合A型肉毒毒素治疗瘢痕疙瘩疗效肯定,能改善瘢痕厚度、瘢痕面积、痛痒程度,并且不会明显增加不良反应发生率、复发率。
Objective Comparison of the efficacy of freezing combined with botulinum toxin type A versus botulinum toxin type A alone in the treatment of keloids.Methods A total of 98 keloid patients admitted to the No.981 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army from April 2017 to April 2020 were selected as the subjects of this study and were divided into two groups according to the randomized numerical table method,with 49 cases in the control group given botulinum toxin type A and 49 cases in the study group treated with combined freezing on the basis of the control group.The two groups were compared in terms of efficacy,scar thickness,scar area,degree of pain and itching,incidence of adverse reactions and recurrence.Results The total effective rate of the study group was 93.88%(46/49),which was higher than that of the control group(71.43%,35/49)(P<0.05).After treatment,the scar thickness,scar area,and degree of pain and itching in the two groups were lower than before treatment(P<0.05),and after treatment,the scar thickness,scar area,pain and itching degree of both groups were lower than that before treatment(P<0.05),and the scar thickness,scar area,pain and itching degree of the study group was lower than that of the control group after treatment(P<0.05).The total incidence of adverse reactions in the study group was 12.24%(6/49)compared with 10.20%(5/49)in the control group,and the difference was not statistically significant(P>0.05).At the 6-month follow up after complete treatment,there were 12 recurrences in the control group and 8 recurrences in the study group,with a recurrence rate of 16.33%in the study group compared with 24.49%in the control group,and the difference was not statistically significant(P>0.05).Conclusion The efficacy of freezing combined with botulinum toxin type A in the treatment of keloid scars is certain,and it can improve the scar thickness,scar area,pain and itchiness without significantly increasing the incidence of adverse reactions or recurrence rates.
作者
李建平
赵磊
田艳伟
李立静
王海艳
LI Jianping;ZHAO Lei;TIAN Yanwei;LI Lijing;WANG Haiyan(Department of Dermatology,No.981 Hospital,Joint Logistics Support Force of the Chinese People's Liberation Army,Chengde,Hebei 067000,China;Department of Obstetrics and Gynecology,Affiliated Hospital of Chengde Medical College,Chengde,Hebei 067000,China)
出处
《安徽医药》
CAS
2023年第9期1836-1839,共4页
Anhui Medical and Pharmaceutical Journal
基金
承德市科学技术局资助项目(202109A100)。
关键词
瘢痕疙瘩
冷冻疗法
A型肉毒毒素
疗效
Keloid
Cryotherapy
Botulinum toxin type A
Curative effect
