摘要
目的系统评价中国儿童抽动障碍预后的影响因素。方法计算机检索PubMed、EMbase、The Cochrane Library、Web of Science、CBM、维普、万方以及中国知网数据库,全面收集中国儿童抽动障碍预后影响因素的观察性研究,检索时限均为从建库至2022年4月。由两名研究员独立进行文献筛选、资料提取,并选用纽卡斯尔-渥太华量表(NOS)进行纳入文献的质量评价。采用RevMan 5.4软件进行Meta分析。结果检索文献共3572篇,最终纳入10篇,包含2项病例对照研究和8项队列研究,共包含1699例中国抽动障碍患儿。Meta分析结果显示,精神、神经疾病家族史[OR=3.17,95%CI(1.51,6.66)]、共患病[OR=2.55,95%CI(1.68,3.87)]、病情反复频数[OR=3.65,95%CI(2.06,6.48)]、病情严重程度[OR=1.52,95%CI(1.19,1.94)]、反复呼吸道感染[OR=1.33,95%CI(1.22,1.44)]、家庭环境[OR=3.00,95%CI(1.50,5.99)]是影响中国儿童抽动障碍预后的危险因素。结论精神、神经疾病家族史、共患病、病情反复频数、病情严重程度、反复呼吸道感染、家庭环境与中国儿童抽动障碍预后不佳相关。
Objective To systematically evaluate the risk factors influencing the prognosis of tic disorders(TD)in Chinese children.Methods The observational studies on the factors affecting the prognosis of children with TD were retrieved in electronic Chinese and English databases from their inception to April 2022,including PubMed,EMbase,The Cochrane Library,Web of Science,CBM,VIP,Wanfang and CNKI.Two researchers independently screened the literature,extracted the data,and evaluated the included literatures using NOS scale.RevMan 5.4 software was used for meta-analysis.Results A total of 3572 articles were retrieved,and 10 articles were finally included,including 2 case-control studies and 8 cohort studies,with a total of 1699 TD children.The results of Meta-analysis showed that family history of mental and neurological diseases[OR=3.17,95%CI(1.51,6.66)],comorbidity[OR=2.55,95%CI(1.68,3.87)],frequency of disease recurrence[OR=3.65,95%CI(2.06,6.48)],disease severity[OR=1.52,95%CI(1.19,1.94)],repeated respiratory infection[OR=1.33,95%CI(1.22,1.44)],and family environment[OR=3.00,95%CI(1.50,5.99)]were risk factors influencing the prognosis of tic disorders in Chinese children.Conclusion Family history of mental and neurological disorders,comorbidities,frequency of TD recurrence,severity of disease,recurrent respiratory infection and family environment are associated with poor prognosis of tic disorders in Chinese children.
作者
郭徵艺
阳柯佳
雷静
曾永渐
郭芝东
孙香娟
GUO Zhiyi;YANG Kejia;LEI Jing;ZENG Yongjian;GUO Zhidong;SUN Xiangjuan(Clinical Medical College of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)
出处
《中国中西医结合儿科学》
2023年第4期283-290,共8页
Chinese Pediatrics of Integrated Traditional and Western Medicine
关键词
抽动障碍
预后
影响因素
系统评价
Tic disorders
Prognosis
Influencing factors
Systematic review
