摘要
目的:建立QuEChERS-超高液相色谱/串联质谱法测定药材中农药残留,并评定其不确定度。方法:按照《中国药典》2020版四部通则第五法测定药材中农药残留,评定不确定度。结论:对炒白术中农药残留不确定度评定影响最大的是农残对照品溶液配制,其次为仪器校准、回收率、样品重复性、样品称量、体积变化。通过对不确定度分量进行量化和合成,表明炒白术样品中甲拌磷亚砜残留为0.081mg/kg,扩展不确定度为0.005 mg/kg(k=2),该方法为科学评价QuEChERS-超高液相色谱/串联质谱法测定药材中农药残留的测量结果的准确性提供参考。
Objective:to establish a QUECHERS-UPLC/ms/ms method for the determination of pesticide residues in medicinal materials and to evaluate its uncertainty.Methods:according to the fifth method of Chinese pharmacopoeia(2020 edition),the pesticide residues in medicinal materials were determined and the uncertainty was evaluated.Conclusion:the most influential factor on the uncertainty of pesticide residues in fried atractylodes macrocephala is the formulation of pesticide control solution,followed by instrument calibration,recovery,sample reproducibility,sample weighing,volume change.By quantifying and synthesizing the uncertainty components,the results showed that the residue of pho in Chinese fried atractylodes macrocephala was 0.081 mg/kg,and the expanded uncertainty was 0.005 mg/kg(K=2),this method provides a scientific reference for evaluating the accuracy of QUECHERS-UPLC/ms determination of pesticide residues in medicinal materials.
作者
邹艺荣
洪家顺
Zou Yi-rong;Hong Jia-shun(Jiangxi Wantuo Environmental Testing Co,Ltd.,Shangrao Jiangxi 334000,China;Jiangxi Province evaluation and research center of daodi herbs,Nanchang Jiangxi 330029,China)
出处
《江西化工》
CAS
2023年第4期47-51,共5页
Jiangxi Chemical Industry
关键词
甲拌磷亚砜
炒白术
不确定度
超高液相色谱/串联质谱法
phorate sulfoxide
fried atractylodes macrocephala
uncertainty
liquid chromatography-tandem mass spectrometry
