摘要
目的 研究肝硬化疾病诊断中应用生化检验项目的价值。方法 选取2021年1月-2022年12月常熟市第五人民医院60例确诊为肝硬化疾病的患者(肝硬化组)与60例非肝硬化疾病患者(非肝硬化组)为研究对象,分别作为肝硬化组和非肝硬化组,比较两组肝功能指标、纤维病变情况及肝硬化分级患者纤维病变情况。结果肝硬化组胆碱酯酶(2 235.12±69.14)U/L、总蛋白(12.54±1.32)g/L低于非肝硬化组(8 320.12±87.15)U/L、(85.02±5.12)g/L,差异有统计学意义(t=423.697、106.181,P<0.05)。肝硬化组总胆红素、γ-谷氨酰转肽酶、天冬氨酸氨基转移酶、丙氨酸氨基转移酶水平高于非肝硬化组,差异有统计学意义(P<0.05)。肝硬化组Ⅲ型前胶原、层粘连蛋白、透明质酸水平均高于非肝硬化组,差异有统计学意义(P<0.05)。A级患者Ⅲ型前胶原、层黏连蛋白水平高于B级患者,且B级患者高于C级患者,差异有统计学意义(P<0.05)。A级患者透明质酸水平低于B级患者,且B级患者低于C级患者,差异有统计学意义(P<0.05)。结论 肝硬化疾病诊断中应用生化检验项目能够区分患者与非患者的肝功能状况,了解肝组织纤维病变状况,并可以将肝硬化患者精准分级,为肝硬化疾病诊断及治疗提供重要的检验支持。
Objective To investnigate the value of applying biochemical test items in the diagnosis of liver cirrhosis.Methods From January 2021 to December 2022,60 patients with liver cirrhosis(liver cirrhosis group)and 60 patients with non liver cirrhosis(non cirrhotic group)were selected as a research object from the Fifth People´s Hospital of Changshu City to compare the liver function indicators,fibropathy and fibropathy in patients with liver cirrhosis grad⁃ing between the two groups.Results The levels of cholinesterase(2235.12±69.14)U/L and total protein(12.54±1.32)g/L in patients with liver cirrhosis group were lower than those in non liver cirrhosis group(8320.12±87.15)U/L and(85.02±5.12)g/L,the difference was statistically significant(t=423.697,106.181,P<0.05).The levels ofγ-glu⁃tamyl transpeptidase,total bilirubin,aspartate transaminase and alanine aminotransferase in patients with liver cirrho⁃sis group were significantly higher than those of non cirrhotic group,the difference was statistically significant(P<0.05).The levels of typeⅢprocollagen,Laminin and hyaluronic acid in patients with liver cirrhosis group were higher than those in non cirrhotic group,and the difference was statistically significant(P<0.05).The levels of typeⅢprocol⁃lagen and Laminin in patients with grade A were higher than those in patients with grade B,and those in patients with grade B were higher than those in patients with grade C,the difference was statistically significant(P<0.05).The level of hyaluronic acid in grade A patients was lower than that in grade B patients,and grade B patients was lower than that in grade C patients,the difference was statistically significant(P<0.05).Conclusion The application of biochemical testing items in the diagnosis of liver cirrhosis can distinguish the liver function status of patients from non pa⁃tients,understand the status of liver tissue fibrosis,and accurately grade liver cirrhosis patients,providing important testing support for the diagnosis and treatment of liver cirrhosis.
作者
宣明怡
XUAN Mingyi(Department of Laboratory,Changshu Fifth People´s Hospital,Changshu,Jiangsu Province,215500 China)
出处
《系统医学》
2023年第11期94-97,共4页
Systems Medicine
关键词
肝硬化疾病诊断
生化检验项目
纤维病变
肝功能
疾病分级
Cirrhosis diagnosis
Biochemical test
Fibrotic lesions
Liver function
Disease classification
