摘要
目的分析内镜下NTAN注射术配合艾普拉唑治疗非静脉曲张性上消化道出血的临床疗效。方法选取2021年11月—2022年11月盐城市第一人民医院收治的100例非静脉曲张性上消化道出血患者作为研究对象,按照随机数表法分为研究组与对照组,每组50例。对照组采用艾普拉唑治疗,研究组在对照组基础上联用内镜下NTAN注射术,对比两组临床疗效。结果研究组有效止血率为94.00%,高于对照组的80.00%,差异有统计学意义(χ^(2)=4.332,P<0.05)。研究组再出血率为4.00%,低于对照组的18.00%,差异有统计学意义(χ^(2)=5.005,P<0.05)。研究组不良反应发生率为4.00%,低于对照组的16.00%,差异有统计学意义(χ^(2)=4.000,P<0.05)。研究组治疗后促胃液素水平(73.28±4.06)μmol/L低于对照组(86.06±6.08)μmol/L,胆囊收缩素水平(12.47±1.00)μmol/L低于对照组(17.18±2.51)μmol/L,大便潜血转阴时间(2.20±0.84)d短于对照组(4.90±0.97)d,呕血停止时间(2.01±0.28)d短于对照组(4.03±0.49)d,住院时间(5.97±1.01)d短于对照组(9.79±2.13)d,差异有统计学意义(t=12.361、12.327、14.879、25.309、11.459,P<0.05)。结论内镜下NTAN注射术配合艾普拉唑能够提高非静脉曲张性上消化道出血患者有效止血率,并加快免疫系统恢复,调节胃肠激素分泌平衡,且治疗安全性较高,具有良好的实用价值。
Objective To analyze the clinical efficacy of endoscopic NTAN injection with ilaprazole in the treatment of non-variceal upper gastrointestinal bleeding.Methods A total of 100 patients with non-varicose upper digestive tract hemorrhage admitted to Yancheng First People's Hospital from November 2021 to November 2022 were selected as research objects and divided into study group and control group according to random number table method,with 50 cases in each group.The control group was treated with iprrazole,and the research group was treated with endoscopic NTAN injection on the basis of the control group,and the clinical efficacy of the two groups was compared.Results The effective hemostasis rate of the study group was 94.00%,higher than 80.00%of the control group,the difference was statistically significant(χ^(2)=4.332,P<0.05);the rebleeding rate of the study group was 4.00%,lower than 18.00%of the control group,the difference was statistically significant(χ^(2)=5.005,P<0.05).The incidence of adverse reactions in the study group was 4.00%,lower than that in the control group(16.00%),and the difference was statistically sig⁃nificant(χ^(2)=4.000,P<0.05).After treatment,the level of gastrin in the study group(73.28±4.06)μmol/L was lower than that in the control group(86.06±6.08)μmol/L,and the level of cholecystokinin(12.47±1.00)μmol/L was lower than that in the control group(17.18±2.51)μmol/L,the duration of fecal occult blood to turn negative(2.20±0.84)d was shorter than that of the control group(4.90±0.97)d,the duration of hematemesis(2.01±0.28)d was shorter than that of the control group(4.03±0.49)d,and the duration of hospitalization(5.97±1.01)d was shorter than that of the control group(9.79±2.13)d,the difference was statistically significant(t=12.361,12.327,14.879,25.309,11.459,P<0.05).Conclusion Endoscopic NTAN injection with ilaprazole can improve the effective hemostasis rate of patients with non-variceal upper gastrointestinal bleeding,and accelerate the recovery of the immune system,regulate the bal⁃ance of gastrointestinal hormone secretion,and the therapeutic safety is high,which has good practical value.
作者
董锦
杨红梅
姜中华
DONG Jin;YANG Hongmei;JIANG Zhonghua(Department of Gastroenterology,Yancheng First People's Hospital,Yancheng,Jiangsu Province,224000 China)
出处
《系统医学》
2023年第12期115-119,共5页
Systems Medicine
