摘要
目的:系统评价脑卒中患者衰弱发生率及与不良结局的关系。方法:计算机检索PubMed、Web of Science、SCOPUS、The Corchane Library、CINAHL、EMbase、MEDLINE、中国知网、维普、中国生物医学文献数据库、万方数据库,检索时限为建库至2022年10月。采用Stata 16.0进行Meta分析,采用Egger’s法判断发表偏倚。结果:最终纳入26篇文献。Meta分析结果显示,脑卒中患者衰弱的总体发生率为40%(95%CI 30%~49%),衰弱前期的总体发生率为45%(95%CI 34%~55%);亚组分析结果显示,女性脑卒中患者的衰弱发生率(35%)高于男性(28%);采用Tilburg衰弱量表进行评估时,脑卒中患者的衰弱发生率(75%)高于其他衰弱评估工具;亚洲地区脑卒中患者的衰弱发生率(48%)更高。衰弱与脑卒中患者不良结局关系:衰弱可增加脑卒中患者死亡的风险(OR=3.23,95%CI 2.13~4.90,P<0.01),衰弱较非衰弱脑卒中患者认知障碍风险增加4.98倍(OR=4.98,95%CI 1.69~14.71,P<0.01)。描述性分析结果显示,衰弱可导致脑卒中患者住院时间延长,增加再住院率和抑郁风险。结论:脑卒中患者的衰弱发生率较高,而衰弱前期的发病率则更高,衰弱可能是脑卒中患者不良结局的危险因素之一。
Objective:To systematically review the incidence of frailty in stroke patients and their relationship with adverse outcomes.Methods:A comprehensive search was conducted in electronic databases,including PubMed,Web of Science,SCOPUS,The Cochrane Library,CINAHL,EMBASE,MEDLINE,CNKI,VIP,SinoMed,and Wanfang Database,from inception to October 2022.The stata 16.0 was used for Meta-analysis and Egger’s method was used to determine publication bias.Results:A total of 26 studies were included.The results of Meta-analysis showed that the overall incidence of frailty in stroke patients was 40%(95%CI 30%-49%),and the overall incidence of pre-frailty was 45%(95%CI 34%-55%).The subgroup analysis showed that the incidence of frailty was higher in female(35%)than in male(28%).Using the Tilburg Frailty Scale,the incidence of frailty in stroke patients was 75%,which was higher than that of other frailty assessment tools.Stroke patients in Asia have a higher incidence of frailty(48%).Association of frailty with adverse outcomes in stroke patients:frailty increased the risk of death in stroke patients(OR=3.23,95%CI 2.13-4.90,P<0.01),and the risk of cognitive impairment in frailty patients was increased by 4.98 times(OR=4.98,95%CI 1.69-14.71,P<0.01).Descriptive analysis showed that frailty in stroke patients can lead to longer hospital stays,increased readmission rate,and increased risk of depression in stroke patients.Conclusion:The incidence of frailty is higher in stroke patients,with a higher incidence of frailty in the pre-frailty stage.Frailty may be a risk factor for adverse outcomes in stroke patients.
作者
刘蕾
何春渝
杨嘉欣
蒋艳萍
周均
郑思婷
LIU Lei;HE Chunyu;YANG Jiaxin;JIANG Yanping;ZHOU Jun;ZHENG Siting(School of Nursing,Chengdu Medical College,Chengdu 610083,China;Department of Neurology,the Second Affiliated Hospital of Chengdu Medical College,Chengdu 610066,China)
出处
《现代医学》
2023年第6期823-830,共8页
Modern Medical Journal
基金
成都医学院-成都医学院第二附属医院联合科研基金资助项目(2022LHFSSYB-07)
成都医学院研究生科研创新基金资助项目(YCX2022-01-45)。
