摘要
目的:观察十二味乌梅汤治疗丑时夜醒型失眠的临床疗效。方法:将睡眠持续困难、以丑时(1∶00~3∶00)夜醒为主症的失眠志愿者148例随机分为治疗组(74例)、对照1组(37例)、对照2组(37例)。治疗组采用十二味乌梅汤加西药安慰剂治疗,对照1组采用艾司唑仑加中药安慰剂治疗,对照2组采用西药安慰剂加中药安慰剂治疗,比较3组治疗前后中医证候积分、匹兹堡睡眠指数量表(PSQI)积分、不良反应和临床疗效。结果:治疗组、对照1组、对照2组总有效率分别为98.65%(73/74)、67.57%(25/37)、5.41%(2/37),治疗组与对照1组、对照2组比较,以及对照1组与对照2组比较,差异均有统计学意义(P<0.05)。治疗后,治疗组较本组治疗前中医证候积分、PSQI积分均有所降低,且与对照1组、对照2组比较,差异均有统计学意义(P<0.01)。3组在治疗过程中均未出现不良反应。结论:十二味乌梅汤治疗睡眠持续困难、丑时夜醒型失眠的患者,不仅能提高其睡眠质量,还可显著改善诸多伴随症状,具有较好的临床适用性。
Objective:To investigate the clinical effect of twelve-ingredient Fructus Mume decoction in the treatment of insomnia with nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.Methods:A total of 148 volunteers with insomnia who had the main symptoms of persistent difficulties in sleeping and nighttime a-wakenings during the period of the day from 1 a.m.to 3 a.m.were enrolled and randomly divided into treatment group with 74 volunteers,control group 1 with 37 volunteers,and control group 2 with 37 volunteers.The volunteers in the treatment group were given twelve-ingredient Fructus Mume decoction combined with Western medicine pla-cebo,those in the control group 1 were given estazolam combined with traditional Chinese medicine(TCM)placebo,and those in the control group 2 were given Western medicine placebo combined with TCM placebo.The three groups were compared in terms of TCM syndrome score,Pittsburgh Sleep Quality Index(PSQI)score,adverse reac-tions,and clinical outcome before and after treatment.Results:The overall response rate was 98.65%(73/74)in the treatment group,67.57%(25/37)in the control group 1,and 5.41%(2/37)in the control group 2,and there was a significant difference between the treatment group and the control groups 1/2 and between the control group 1 and the control group 2(P<0.05).After treatment,the treatment group had reductions in TCM syndrome score and PSQI score,and there were significant differences between the treatment group and the control groups 1/2(P<0.01).No adverse reactions were observed during treatment.Conclusion:In the treatment of insomnia with persis-tent difficulties in sleeping and nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.,twelve-ingredient Fructus Mume decoction can improve sleep quality and various accompanying symptoms and has good clinical applicability.
作者
陆素琴
顾植山
吴贞
景慧
范魏伟
徐利飞
LU Suqin;GU Zhishan;WU Zhen;JING Hui;FAN Weiwei;XU Lifei(Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine/Zhenjiang Hospital of Traditional Chinese Medicine,Zhenjiang 212000,Jiangsu,China;Wuxi Huishan Hospital of Traditional Chinese Medicine,Wuxi 214100,Jiangsu,China)
出处
《湖南中医杂志》
2023年第7期7-10,29,共5页
Hunan Journal of Traditional Chinese Medicine
基金
江苏省镇江市“金山医者”医学领域人才培养项目
江苏省镇江市科技创新资金(重点研发计划——社会发展)项目(SH2021077)
江苏省镇江市第三批老中医药专家学术经验继承项目(镇卫中医2022[7]号)。
关键词
失眠
丑时夜醒
十二味乌梅汤
中医证候积分
匹兹堡睡眠指数量表
insomnia
nighttime awakenings during the period of the day from 1 a.m.to 3 a.m.
traditional Chinese medicine syndrome score
Pittsburgh Sleep Quality Index
