摘要
目的分析太原市体检人群甲状腺结节(TN)的患病情况,探讨高尿酸血症(HUA)对TN发病风险的影响。方法采用前瞻性设计,选取2020年10月至2021年10月在山西尚宁健康体检中心进行常规体检的42966名人群作为研究对象。根据血清尿酸水平分为HUA组(n=7235)与非HUA组(n=35731),利用倾向性评分匹配(PSM)法均衡组间的混杂因素,结合logistic回归分析HUA对TN发病风险的影响。结果体检人群的TN总检出率为55.6%(23907/42966),女性TN检出率[61.0%(15011/24618)]高于男性[48.5%(8896/18348)],差异有统计学意义(χ^(2)=664.55,P<0.001)。PSM后共得到2438对匹配资料,HUA组与非HUA组各混杂因素的分布均达到均衡(标准化差值的绝对值均<0.10)。logistic回归分析显示,PSM前总人群及男性中,HUA均是TN发病的保护因素[比值比(OR)=0.696、0.817,95%置信区间(CI):0.661~0.732、0.768~0.868];而在女性中,HUA是TN发病的危险因素(OR=1.370,95%CI:1.192~1.574)。PSM后总人群及男性中,HUA对TN发病风险的影响均无统计学意义(均P>0.05);而在女性中,HUA仍是TN发病的危险因素(OR=1.373,95%CI:1.014~1.858)。结论在太原市体检人群中,HUA是女性TN发病的独立危险因素。
Objective To investigate the prevalence of thyroid nodules(TN)among people undergoing physical examination in Taiyuan City,and evaluate the impact of hyperuricemia(HUA)on the risk of TN.Methods Using a prospective design,a total of 42966 people who underwent routine physical examination at Shanxi Shangning Health Examination Center from October 2020 to October 2021 were selected as subjects and divided into the HUA group(n=7235)and the non-HUA group(n=35731)based on the serum uric acid levels.The propensity score matching(PSM)method was used to balance the confounding factors between groups,and logistic regression was used to analyze the impact of HUA on the risk of TN.Results The total detection rate of TN in the physical examination population was 55.6%(23907/42966).The detection rate of TN in females[61.0%(15011/24618)]was higher than that in males[48.5%(8896/18348)],and the difference was statistically significant(χ^(2)=664.55,P<0.001).A total of 2438 pairs of matching data were obtained after PSM,and the distribution of confounding factors in HUA and non-HUA groups reached equilibrium(the absolute values of standardized diferences<0.10).Logistic regression analysis before PSM showed that HUA was a protective factor for the incidence of TN in general population and males[odds ratio(OR)=0.696,0.817,95%confidence interval(CI):0.661-0.732,0.768-0.868],while HUA was a risk factor for the incidence of TN in females(OR=1.370,95%CI:1.192-1.574).After PSM,HUA was not a influencing factor for the incidence of TN in general population and males(P>0.05),but it was still a risk factor in females for the onset of TN(OR=1.373,95%CI:1.014-1.858).Conclusion In the physical examination population in Taiyuan City, HUA is an independent risk factor for TN in females.
作者
杨爽
渠鹏霞
刘岳楠
李静
郭耀文
李元宾
王丽华
Yang Shuang;Qu Pengxid;Liu Yuenan;Li Jing;Guo Yaowen;Li Yuanbin;Wang Lihua(Department of Endocrinology,Taiyuan City Central Hospital,Ninth Clinical Medical College of Shanxi Medical University,Taiyuan 030000,China;Health Management Department,Shanxi Shangning Health Examination Center,Taiyuan 030000,China)
出处
《中华地方病学杂志》
CAS
北大核心
2023年第6期439-446,共8页
Chinese Journal of Endemiology
基金
山西省卫生健康委科研课题(晋卫办科教函[2022]4号2022084)。
