摘要
中药水提液成分复杂,随着中药制药的发展,迫切需要建立一种简单有效的中药分离纯化方法。膜分离技术作为一种简单、直接、高效的物质分离方法,在中药分离纯化中由于能耗低、无二次污染而被广泛应用。本工作通过制备不同孔径的核孔膜,将中药水提液进行多级过滤,并对其分离性能进行测试和表征。实验证实核孔膜对水提液的微滤可以滤除尺度1μm以上的杂质,且不改变其性状;对水提液的超滤可以滤除蛋白质和淀粉;核孔膜进一步修饰后,能够对中药有效成分,如芍药苷、绿原酸等进行有效截留。结果表明,将核孔膜应用于中药水提液分离、纯化是可行的。
The components of Chinese medicine water extract are complex.With the development of traditional Chinese medicine pharmacy,it is urgent to establish a simple and effective separation and purification method for traditional Chinese medicine.Membrane separation technology,as a simple,direct and efficient material separation method,is widely used in the separation and purification of traditional Chinese medicine because of its low energy consumption and no secondary pollution.Using the ion-track etched membrane with different pore diameters to filter the Chinese medicine water extract in multiple steps,and characterizing the filtrate.The impurities above 1μm can be removed through microfiltration without changing the properties of water extract.Besides,the proteins and starches can also be removed through ultrafiltration.After modification,the active components of traditional Chinese medicine,like paeoniflorin and chlorogenic acid,can be separated by the iontrack etched membrane.The results show that the ion-track etched membrane can be applied to the process of separation and purification of Chinese medicine water extract,which proves that the ion-track etched membrane can be used for the separation and purification of Chinese medicine water extract.
作者
王星凡
马圣明
桂小钰
马靖怡
莫丹
段敬来
刘杰
姚会军
WANG Xingfan;MA Shengming;GUI Xiaoyu;MA Jingyi;MO Dan;DUAN Jinglai;LIU Jie;YAO Huijun(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China;University of Chinese Academy of Sciences,Beijing 100049,China;Adcanced Energy Science and Technology Guangdong Laboratory,Huizhou 516000,Guangdong,China)
出处
《原子核物理评论》
CAS
CSCD
北大核心
2023年第2期264-272,共9页
Nuclear Physics Review
基金
国家重点研发计划资助项目(Y91O171KJ1)
国家自然科学基金资助项目(Y850020GJ0)。
关键词
核孔膜
中药澄清精制
膜工艺
ion-track etched membrane
clarification and refinement of traditional Chinese medicine
membrane process
