摘要
目的 分析对2型糖尿病患者应用达格列净联合胰岛素强化治疗对其血糖指标、血脂指标指标、血糖波动指标、脂联素、氮末端B型脑钠肽(N-terminal B-type natriuretic peptide,NT-proBNP)、白介素-6(interleukin-6,IL-6)与超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)指标的影响。方法 选取泗洪县第一人民医院2021年3月—2023年3月收治的87例2型糖尿病患者,按治疗方法分为两组,对照组43例,观察组44例,对照组予达格列净治疗,观察组在对照组基础上联合胰岛素强化治疗。比较两组血糖指标、血脂指标、血糖波动指标、脂联素、NT-proBNP、IL-6与hs-CRP指标。结果 治疗后,观察组空腹血糖、糖化血红蛋白与餐后2 h血糖指标均低于对照组,空腹血清胰岛素指标[(15.35±2.68)μU/mL]高于对照组[(10.53±2.06)μU/mL],差异有统计学意义(t=12.488、6.819、9.498、9.390,P<0.05);观察组总胆固醇与三酰甘油水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,差异有统计学意义(P<0.05);观察组各项血糖波动相关指标均低于对照组,差异有统计学意义(P<0.05);观察组脂联素指标高于对照组,NT-proBNP、IL-6与hs-CRP水平低于对照组,差异有统计学意义(P<0.05)。结论 达格列净联合胰岛素强化疗法能够合理控制2型糖尿病的血糖指数,降低血糖与血脂的相关指标。
Objective To analyze the effects of intensive treatment of type 2 diabetes mellitus patients with dapagliflozin combined with insulin on their blood glucose indexes,lipid indexes,blood glucose fluctuation indexes,and the indexes of lipocalin,N-terminal B-type natriuretic peptide(NT-proBNP),interleukin-6(IL-6) and hypersensitive C-reactive protein(hs-CRP).Methods 87 cases of type 2 diabetes patients admitted to Sihong First People's Hospital from March 2021 to March 2023 were selected and divided into two groups according to the treatment methods,43 cases in the control group and 44 cases in the observation group.The control group was treated with dapagliflozin,and the observation group was treated with insulin intensive therapy on the basis of the control group.The indexes of blood glucose,blood lipid,blood glucose fluctuation,adiponectin,NT-proBNP,IL-6 and hs-CRP were compared between the two groups.Results After treatment,the fasting plasma glucose,glycosylated hemoglobin and 2-hour postprandial blood glucose in the observation group were lower than those in the control group,and the fasting serum insulin index [(15.35±2.68) μU/mL] were higher than those in the control group [(10.53±2.06) μU/mL],and the difference was statistically significant(t=12.488,6.819,9.498,9.390,P<0.05).The total cholesterol and triacylglycerol levels of the observation group were lower than those of the control group,and the HDL cholesterol level was higher than that of the control group,and the difference was statistically significant(P<0.05).All blood glucose fluctuation-related indexes in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The adiponectin index in the observation group was higher than that in the control group,and the levels of NT-proBNP,IL-6 and hs-CRP were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Dapagliflozin combined with insulin intensive therapy can reasonably control the blood glucose index of type 2 diabetes mellitus and reduce the related indexes of blood glucose and blood lipid.
作者
高念吉
朱磊
GAO Nianji;ZHU Lei(Department of Endocrinology,Sihong First People's Hospital,Sihong,Jiangsu Province,223900 China)
出处
《糖尿病新世界》
2023年第15期107-110,共4页
Diabetes New World Magazine
关键词
2型糖尿病
达格列净
胰岛素强化治疗
血糖指标
血脂指标
血糖波动指标
Type 2 diabetes mellitus
Dapagliflozin
Insulin intensive therapy
Blood glucose index
Blood lipid index
Blood glucose fluctuation index
