摘要
目的探讨妊娠早、中、晚期血清维生素D水平与子痫前期发生风险的相关性。方法回顾性选择2020年8月至2021年7月在首都医科大学电力教学医院建档并分娩的孕妇纳入研究,妊娠期间发生子痫前期的150例孕妇作为病例组,按照1∶4匹配原则(年龄、孕前体质量指数及末次月经)选取最终分娩后无任何合并症的600例孕妇作为对照组。比较两组妊娠早、中、晚期血清维生素D水平的差异,应用二元Logistic回归模型分析妊娠不同时期血清维生素D水平与子痫前期发生风险的关联性。结果病例组妊娠早、中、晚期血清维生素D水平均低于对照组[(14.32±3.61)μg/L比(18.78±4.73)μg/L、(15.06±3.12)μg/L比(19.88±4.25)μg/L、(16.04±3.51)μg/L比(22.04±5.63)μg/L],差异有统计学意义(P<0.05)。以维生素D水平充足为参照组,校正孕期增重、是否初产等多项混杂因素后,在孕早期,维生素D水平严重缺乏、缺乏和不足的孕妇发生子痫前期风险均增加,OR值和95%CI分别为4.84(1.25~31.42)、3.09(1.12~8.96)、1.48(1.12~13.05);在孕中期,维生素D水平严重缺乏、缺乏和不足的孕妇发生子痫前期风险均增加,OR值和95%CI分别为4.43(1.23~13.55)、2.22(1.05~6.78)、1.12(0.45~7.73);在孕晚期,维生素D水平严重缺乏、缺乏和不足的孕妇发生子痫前期风险均增加,OR值和95%CI分别为2.13(1.12~8.64)、1.76(1.02~4.98)、1.22(0.72~3.94)。结论妊娠早、中、晚期孕妇血清维生素D水平均与子痫前期发生风险存在相关性,当孕期血清维生素D水平处于严重缺乏和缺乏时,孕妇子痫前期发生风险显著增加。
Objective To investigate the correlation between serum vitamin D and the risk of pre-eclampsia at the early,middle and late stages of pregnancy.Methods Pregnant women who registered and delivered in Electric Power Teaching Hospital of Capital Medical University from August 2020 to July 2021 were included.Pregnant women with pre-eclampsia during pregnancy were selected as the case group(150 cases),while pregnant women without any complications after delivery were selected as the control group(600 cases)according to the 1∶4 matching principle(age,pre-pregnancy body mass index and last menstruation).The levels of serum vitamin D in differences stages of pregnancy between the two groups were compared.Logistic regression model was used to analyze the association between serum vitamin D levels and the risk of pre-eclampsia.Results The levels of serum vitamin D at the early,middle and late stages of pregnancy in the case group were lower than those in the control group:(14.32±3.61)μg/L vs.(18.78±4.73)μg/L,(15.06±3.12)μg/L vs.(19.88±4.25)μg/L,(16.04±3.51)μg/L vs.(22.04±5.63)μg/L,there were statistical differences(P<0.05).Taking pregnant women with adequate serum Vitamin D as a reference,and adjusting for confounding factors such as gain weight and primipara,the risk of pre-eclampsia in early stages pregnant women with serum Vitamin D serious deficiency,middle deficiency and deficiency was increased and the OR and 95%CI were 4.84(1.25-31.42),3.09(1.12-8.96),1.48(1.12-13.05);the risk of pre-eclampsia in middle stages pregnant women with serum vitamin D serious deficiency,middle deficiency and deficiency was increased and the OR(95%CI)were 4.43(1.23-13.55),2.22(1.05-6.78),1.12(0.45-7.73);the risk of pre-eclampsia in late stages pregnant women with serum vitamin D serious deficiency,middle deficiency and deficiency was increased and the OR(95%CI)were 2.13(1.12-8.64),1.76(1.02-4.98),1.22(0.72-3.94).Conclusions The level of serum vitamin D is associated with the risk of pre-eclampsia in pregnant women in the early,middle and late stages of pregnancy,and the risk of pre-eclampsia is significantly increase when the level of serum vitamin D is severely deficient or deficient during pregnancy.
作者
刘永红
李露
曹丽莎
陈升平
Liu Yonghong;Li Lu;Cao Lisha;Chen Shengping(Department of Gynaecology and Obstetrics,Electric Power Teaching Hospital of Capital Medical University,Beijing 100074,China)
出处
《中国医师进修杂志》
2023年第8期715-718,共4页
Chinese Journal of Postgraduates of Medicine
关键词
妊娠初期
妊娠中期
妊娠末期
维生素D
先兆子痫
Pregnancy trimester,first
Pregnancy trimester,second
Pregnancy trimester,third
Vitamin D
Pre-eclampsia
