摘要
目的探讨低级别脑胶质瘤(LGG)患者的预后影响因素。方法回顾性分析cBioPortal数据库中227例LGG患者资料,收集患者的一般信息如性别、年龄、人种、有无癫痫史、有无头部电离辐射史、有无术前使用糖皮质激素、有无伴有其它肿瘤史、基因突变率、首发症状、首发症状持续时间、肿瘤位置、肿瘤部位的偏侧、肿瘤组织学类型、术后有无肿瘤复发、总生存时间、总生存状态(生存或者死亡)及无复发持续时间等。用R语言(version 3.5.2)软件进行统计分析,采用单因素分析筛选对生存状态差异有统计学意义的指标,并进行COX多因素回归分析。结果对227例LGG患者的所有资料进行单因素分析,其中术后有无肿瘤复发、首发症状持续时间、基因突变率及有无伴随其它肿瘤方面比较差异均有统计学意义(P<0.05)。多因素COX分析显示有无伴随其它肿瘤、术前有无使用糖皮质激素及基因突变率3个因素均对患者生存预后有影响。其中有2项指标为危险因素(OR>1),分别为基因突变率(R=52.1107)及有无伴随其它肿瘤(R=2.0590);另外1项指标即术前有无使用糖皮质激素(R=0.3229)为保护因素(OR<1)。结论术前有无使用糖皮质激素、首发症状持续时间长短、基因突变率高低及有无伴随肿瘤均为LGG患者的生存预后影响因素。
Objective To explore the prognostic factors of patients with low-grade glioma(LGG).Methods A retrospective analysis was conducted on the data of 227 LGG patients from cBioPortal database.General patient information were collected,including gender,age,race,whether the patients had histories of epilepsy,head ionizing radiation,preoperative use of glucocorticoids and other tumors,gene mutation rate,initial symptoms,duration of initial symptoms,tumor location,the laterality of tumor sites,histological type of tumor,postoperative tumor recurrence,overall survival time,overall survival status(alive or deceased)and duration of recurrence-free survival,etc..Statistical analysis was performed using R software(version 3.5.2).Univariate analysis was used to screen for indicators with statistically significant differences in survival status,followed by COX multivariate regression analysis.Results Univariate analysis was conducted on all factors of 227 LGG patients'samples,revealing that among which,there were statistically significant differences in postoperative tumor recurrence,duration of initial symptoms,gene mutation rate and whether had other tumors(P<0.05).Multivariate COX analysis showed that the whether had other tumors,preoperative glucocorticoid therapy and gene mutation rate had an impact on the survival and prognosis of the patients,among them,two indicators were risk factors with OR>1:gene mutation rate(R=52.1107)and concomitant tumor status(R=2.0590).Additionally,preoperative use of glucocorticoids was a protective factor with an OR<1.Conclusion The preoperative use of glucocorticoids,duration of initial symptoms,gene mutation rate and presence of concomitant tumors are prognostic factors for survival in patients with LGG.
作者
胡皓月
彭爽
吴旭玲
刘瑛
郑乾
马鹏飞
张敏
叶兰
冯占辉
HU Haoyue;PENG Shuang;WU Xuling(Department of Neurology,the Affiliated Hospital of Guizhou Medical University,Guiyang(550004),Guizhou,China)
出处
《癫痫与神经电生理学杂志》
2023年第4期203-208,共6页
Journal of Epileptology and Electroneurophysiology(China)
基金
国家自然科学基金项目(81860248,8196022d)
中国抗癫痫协会癫痫科研基金项目(2018016)
贵州省卫生健康委科学技术基金(gzwjkj2020-2-005)
贵州省基础研究计划(黔科合基础-ZK[2023]一般395和324)。
