摘要
目的:分析早期食管鳞状细胞癌根治术后患者脂代谢异常与临床预后的相关性。方法:回顾性分析2018年1月至2021年9月该院接受根治术治疗的260例食管癌患者的临床资料,术后均接受为期1年的随访,将出现复发、转移或死亡患者归入预后不佳组,未出现患者归入预后良好组,比较两组脂代谢指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]水平,并分析其与早期食管鳞状细胞癌根治术后患者临床预后的相关性和预测价值。结果:术后随访1年,260例早期食管鳞状细胞癌患者预后不佳34例,占13.08%(34/260);预后不佳组TG、TC水平均高于预后良好组,差异有统计学意义(P<0.05);两组HDL-C、LDL-C水平比较,差异均无统计学意义(P>0.05);Pearson相关性分析结果显示,TG、TC水平与早期食管鳞状细胞癌根治术后患者临床预后呈正相关(r>0,P<0.05);将TG、TC水平作为检验变量,绘制受试者工作特征曲线(ROC),并计算曲线下面积(AUC),结果显示,TG、TC水平单项及联合检测预测早期食管鳞状细胞癌根治术后患者预后的AUC分别为0.730、0.701、0.792,均具有一定预测价值,且联合检测预测价值最高。结论:早期食管鳞状细胞癌根治术后患者脂代谢异常与临床预后呈正相关。
Objective:To analyze correlation between abnormal lipid metabolism and clinical prognosis in patients with early esophageal squamous cell carcinoma after radical resection.Methods:The clinical data of 260 patients with esophageal cancer who underwent radical resection in this hospital from January 2018 to September 2021 were retrospectively analyzed.All patients were followed up for 1 year.The patients with recurrence,metastasis or death were classified into poor prognosis group,and the patients without recurrence were classified into good prognosis group.The levels of lipid metabolism indexes[triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)]were compared between the two groups,and their correlation and predictive value with the clinical prognosis of the patients with early esophageal squamous cell carcinoma after radical resection were analyzed.Results:After 1 year of follow-up,34 of the 260 patients with early esophageal squamous cell carcinoma had poor prognosis,accounting for 13.08%(34/260).The levels of TG and TC in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the levels of HDL-C and LDL-C between the two groups(P>0.05).Pearson correlation analysis showed that the levels of TG and TC were positively correlated with the clinical prognosis of the patients with early esophageal squamous cell carcinoma after radical resection(r>0,P<0.05).Using the levels of TG and TC were as the test variables,the receiver operating characteristic curve(ROC)was drawn,and the area under the curve(AUC)was calculated.The results showed that the AUCs of single and combined detection of TG and TC levels in the prediction of the prognosis of the patients with early esophageal squamous cell carcinoma after radical resection were 0.730,0.701 and 0.792,separately,which had certain predictive value,and the combined detection had the highest predictive value.Conclusions:The abnormal lipid metabolism in the patients with early esophageal squamous cell carcinoma after radical resection is positively correlated with the clinical prognosis.
作者
孙喜明
SUN Ximing(Department of Thoracic Surgery of Shangqiu Third People’s Hospital,Shangqiu 476000 Henan,China)
出处
《中国民康医学》
2023年第15期137-139,共3页
Medical Journal of Chinese People’s Health
关键词
食管鳞状细胞癌
早期
根治术
脂代谢异常
临床预后
相关性
Esophageal squamous cell carcinoma
Early
Radical resection
Abnormal lipid metabolism
Clinical prognosis
Correlation
