摘要
In a rational chiral molecular design of chalcogenides,optically active thiepin with C_(2)-symmetric chirality was synthesized from commercially available thiophene.Then enatioselective Chalcogeno-Baylis-Hillman reactions of arylaldehydes with methyl vinyl ketone(MVK)and acrylates were investigated in the presence of thiepin-Lewis acid complex.Finally,up to 64%ee was achieved in the presence of 0.2 equiv.of(S)-thiepin at 20℃.
基金
The work was partially supported by the Science and Technology Commission of Shanghai Municipality(No.12ZR1431100).Support from Prof.Gang Zhao was also greatly appreciated.
